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公开(公告)号：EP3450456A1
公开(公告)日：2019-03-06
申请号：EP16900649.1
申请日：2016-12-02
发明人： MOROZOV, Dmitry Valentinovich , ULITIN, Andrei Borisovich , ZUBAREVA, Ekaterina Sergeevna , USTIUGOV, Iakov Iurevich , KARABELSKII, Aleksandr Vladimirovich , KORZHAVIN, Dmitry Valeryevich , CHERNOVSKAYA, Tatiana Veniaminovna , GRACHEV, Aleksandr Valerevich , BASOVSKIY, Yury Ivanovich , LOMKOVA, Ekaterina Aleksandrovna , USATOVA, Veronika Sergeevna , ALEKSANDROV, Aleksei Aleksandrovich , MOROZOVA, Elena Leonidovna , IVANOV, Roman Alekseevich , IAKOVLEV, Pavel Andreevich
摘要： The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
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公开(公告)号：EP3693388A1
公开(公告)日：2020-08-12
申请号：EP18864122.9
申请日：2018-10-02
发明人： SOFRONOVA, Ekaterina Vladimirovna , MISORIN, Aleksei Konstantinovich , DORONIN, Aleksandr Nikolaevich , NEMANKIN, Timofey Aleksandrovich , SOZONOVA, Aleksandra Aleksandrovna , ZHIRIVSKAIA, Galina Stepanovna , LEGOTSKY, Sergey Aleksandrovich , VLADIMIROVA, Anna Konstantinovna , BELIASNIKOVA, Alina Valerevna , SHCHEMELEVA, Mariia Aleksandrovna , IAKOVLEV, Pavel Andreevich , SOLOVYEV, Valery Vladimirovich , KRENDELEVA, Elena Andreevna , PESTOVA, Natalia Evgenevna , MOROZOV, Dmitry Valentinovich
摘要： The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.
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