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1.发明公开HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH 审中-公开基于变异VL和衍生VHH的高亲和力和集体稳定的抗体
公开(公告)号：EP3199550A1
公开(公告)日：2017-08-02
申请号：EP15843607.1
申请日：2015-03-23
发明人： ULITIN, Andrey Borisovich , EVDOKIMOV, Stanislav Rudolfovich , SOLOVIEV, Valeriy Vladimirovich , CHERNYH, Yulia Sergeevna , GONCHAROVA, Olga Vladimirovna , KORZHAVIN, Dmitriy Valerievich , CHERNOVSKAYA, Tatyana Veniaminovna , NEMANKIN, Timofey Aleksandrovich , IVANOV, Roman Alexeevich , MOROZOV, Dmitriy Valentinovich , EKIMOVA, Victoria Mikhailovna , SOFRONOVA, Ekaterina Vladimirovna , USTYUGOV, Yakov Yurevich
IPC分类号： C07K16/24 , C07K16/18 , C12N15/13 , A61K39/395
CPC分类号： C07K16/461 , A61K39/3955 , A61K39/39591 , A61K45/06 , C07K16/244 , C07K2317/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V L are offered. The said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
摘要翻译： 提供了包含由VHH-衍生物与轻链VL的可变结构域的组合表示的可变结构域的单克隆IgG型抗体。 所述抗体可以包含在44和45位（Kabat编号）或其组合的氨基酸取代。 本发明的抗体具有增加的亲和力和改善的聚集稳定性。
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公开(公告)号：EP3693388A1
公开(公告)日：2020-08-12
申请号：EP18864122.9
申请日：2018-10-02
发明人： SOFRONOVA, Ekaterina Vladimirovna , MISORIN, Aleksei Konstantinovich , DORONIN, Aleksandr Nikolaevich , NEMANKIN, Timofey Aleksandrovich , SOZONOVA, Aleksandra Aleksandrovna , ZHIRIVSKAIA, Galina Stepanovna , LEGOTSKY, Sergey Aleksandrovich , VLADIMIROVA, Anna Konstantinovna , BELIASNIKOVA, Alina Valerevna , SHCHEMELEVA, Mariia Aleksandrovna , IAKOVLEV, Pavel Andreevich , SOLOVYEV, Valery Vladimirovich , KRENDELEVA, Elena Andreevna , PESTOVA, Natalia Evgenevna , MOROZOV, Dmitry Valentinovich
摘要： The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.
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