公开(公告)号：EP3199550A1

公开(公告)日：2017-08-02

申请号：EP15843607.1

申请日：2015-03-23

申请人： Closed Joint Stock Company "Biocad"

发明人： ULITIN, Andrey Borisovich ,  EVDOKIMOV, Stanislav Rudolfovich ,  SOLOVIEV, Valeriy Vladimirovich ,  CHERNYH, Yulia Sergeevna ,  GONCHAROVA, Olga Vladimirovna ,  KORZHAVIN, Dmitriy Valerievich ,  CHERNOVSKAYA, Tatyana Veniaminovna ,  NEMANKIN, Timofey Aleksandrovich ,  IVANOV, Roman Alexeevich ,  MOROZOV, Dmitriy Valentinovich ,  EKIMOVA, Victoria Mikhailovna ,  SOFRONOVA, Ekaterina Vladimirovna ,  USTYUGOV, Yakov Yurevich

IPC分类号： C07K16/24 ,  C07K16/18 ,  C12N15/13 ,  A61K39/395

CPC分类号： C07K16/461 ,  A61K39/3955 ,  A61K39/39591 ,  A61K45/06 ,  C07K16/244 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V L are offered. The said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

摘要翻译： 提供了包含由VHH-衍生物与轻链VL的可变结构域的组合表示的可变结构域的单克隆IgG型抗体。 所述抗体可以包含在44和45位（Kabat编号）或其组合的氨基酸取代。 本发明的抗体具有增加的亲和力和改善的聚集稳定性。

公开(公告)号：EP3130604A1

公开(公告)日：2017-02-15

申请号：EP14885545.5

申请日：2014-10-27

申请人： Closed Joint Stock Company "Biocad"

发明人： ULITIN, Andrey Borisovich ,  EVDOKIMOV, Stanislav Rudolfovich ,  SOLOVIEV, Valeriy Vladimirovich ,  CHERNYH, Yulia Sergeevna ,  GONCHAROVA, Olga Vladimirovna ,  KORZHAVIN, Dmitriy Valerievich ,  CHERNOVSKAYA, Tatyana Veniaminovna ,  IVANOV, Roman Alexeevich ,  MOROZOV, Dmitriy Valentinovich

IPC分类号： C07K16/24 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  A61K39/395 ,  A61P37/06

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.

摘要翻译： 本发明涉及医药领域，特别涉及针对人IL-17日单克隆抗体领域 更具体地，本发明涉及单克隆抗体/ IL-17A的与IL-17的高亲和力，表位结合拮抗剂，worin抗体包含重链和轻链的高变区的氨基酸取代。 gemäß本发明的抗体可以是嵌合的，人源化或人抗体或其抗原结合片段，并且可以使用作为药剂用于治疗自身免疫和炎性疾病和细胞增殖和发育障碍。 因此，本发明涉及用于产生所述抗体的方法。