公开(公告)号：EP1098986A2

公开(公告)日：2001-05-16

申请号：EP99934910.3

申请日：1999-07-21

申请人： Cobra Therapeutics Limited

发明人： ANTONIOU, Michael,Dept. of Experimental Pathology ,  CROMBIE, Robert,Cobra Therapeutics Limited

IPC分类号： C12N15/85 ,  C12N5/10 ,  C12Q1/68 ,  A61K48/00 ,  C12N15/00 ,  A01K67/027 ,  C12N15/11

CPC分类号： C12N15/11 ,  A01K2217/05 ,  A61K48/00 ,  C12N15/63 ,  C12N15/85 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2830/008 ,  C12N2830/205 ,  C12N2830/42 ,  C12N2830/46 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  C12N2840/44

摘要： The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.