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公开(公告)号：EP3086770B1
公开(公告)日：2019-10-30
申请号：EP13821398.8
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico
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2.发明公开PREBIOTIC ORAL CARE COMPOSITIONS CONTAINING AN ALKYL GLYCOSIDE 有权ÄE ID ID ID ID ID ID ID ID ID ID ID ID ID ID ID ID ID ID
公开(公告)号：EP3086800A1
公开(公告)日：2016-11-02
申请号：EP13821396.2
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico , LOOZEN, Gitte
CPC分类号： A61K8/602 , A61K8/99 , A61K31/7004 , A61K2800/48 , A61Q11/00
摘要： The disclosure relates to an oral care composition an effective amount of at least one C?1-4#191 (optionally hydroxylated) alkyl glycoside, e.g., β-methyl-D-galactoside, wherein the glycoside promotes the growth of beneficial endogenous bacteria and negatively affects the growth of endogenous pathogenic strains of bacteria. The disclosure also relates to methods of use, methods of screening, and methods of manufacture of said oral care compositions.
摘要翻译： 本公开内容涉及口腔护理组合物有效量的至少一种C 1-4-14＃191（任选羟基化）烷基糖苷，例如β-甲基-D-半乳糖苷，其中所述糖苷促进有益的内源性细菌的生长， 对内源性致病菌株的生长有负面影响。 本公开还涉及所述口腔护理组合物的使用方法，筛选方法和制备方法。
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3.发明公开
公开(公告)号：EP3207117A1
公开(公告)日：2017-08-23
申请号：EP14812024.9
申请日：2014-11-11
发明人： STETTLER, Hans , RUSSO, Amy
CPC分类号： G01N33/56955 , C12M1/12 , C12Q1/18
摘要： Disclosed is an in vitro oral biofilm model of interdental spaces including: a support, and a plurality of substratum pairs attached to the support, wherein an oral biofilm is capable of forming on the substratum pairs, wherein the substratum pairs each include a first member and a second member, and wherein the first member and the second member of each substratum pair are arranged to form a space interval between the first member and second member. Methods for assessing the formation of oral biofilms using the in vitro oral biofilm model and methods for testing agents, such as oral compositions, on biofilm reduction using the present model are also provided.
摘要翻译： 公开了齿间空间的体外口腔生物膜模型，其包括：支撑件和附接到支撑件的多个基底对，其中口腔生物膜能够在基底对上形成，其中基底对各自包括第一构件和 第二构件，并且其中每个基底对的第一构件和第二构件被布置为在第一构件和第二构件之间形成空间间隔。 还提供了使用体外口腔生物膜模型评估口腔生物膜形成的方法和用于测试试剂例如口服组合物的方法，其使用本模型对生物膜减少。
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4.发明公开
公开(公告)号：EP3151733A1
公开(公告)日：2017-04-12
申请号：EP15802368.9
申请日：2015-06-08
发明人： RICKARD, Alexander , GIANNOBILE, William , SWETKY, Michelle , MILLER, Steven E. , DU-THUMM, Laurence , STETTLER, Hans , BAXTER, Nielson, T.
摘要： The present disclosure relates to methods for characterizing and diagnosing dental diseases. In particular, the present disclosure relates to methods for characterizing and diagnosing dental disease (e.g., gingivitis and periodontal disease) based on levels of AI-2 in oral fluids and plaque.
摘要翻译： 本发明涉及用于表征和诊断牙科疾病的方法。 特别地，本公开涉及用于表征和诊断基于在口服液体和斑块AI-2的水平牙科疾病（E. G.，牙龈炎和牙周病）的方法。
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公开(公告)号：EP3086796B1
公开(公告)日：2018-10-24
申请号：EP13821399.6
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico
IPC分类号： A61K31/715 , A61K31/70 , A61K31/702 , A61K8/60 , A61Q11/00 , A61K8/25 , A61K8/29 , A61K8/81 , A61K8/34 , A61K8/46 , A61K31/7008 , A61K31/7032 , A61K8/99 , C12Q1/02 , A61K8/73 , A61K8/19 , A61K31/047
CPC分类号： A61K8/60 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/463 , A61K8/73 , A61K8/731 , A61K8/8164 , A61K8/99 , A61K31/047 , A61K31/7008 , A61K31/702 , A61K31/7032 , A61K2800/28 , A61K2800/592 , A61Q11/00 , C12Q1/025 , G01N2500/10
摘要： The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myoinositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
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公开(公告)号：EP3151733B1
公开(公告)日：2020-04-15
申请号：EP15802368.9
申请日：2015-06-08
发明人： RICKARD, Alexander , GIANNOBILE, William , SWETKY, Michelle , MILLER, Steven E. , DU-THUMM, Laurence , STETTLER, Hans , BAXTER, Nielson T.
IPC分类号： G01N33/569 , G16H50/30 , A61B5/00 , C12Q1/18 , C12Q1/68
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公开(公告)号：EP3086800B1
公开(公告)日：2018-05-30
申请号：EP13821396.2
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico , LOOZEN, Gitte
CPC分类号： A61K8/602 , A61K8/99 , A61K31/7004 , A61K2800/48 , A61Q11/00
摘要： The disclosure relates to an oral care composition an effective amount of at least one C?1-4#191 (optionally hydroxylated) alkyl glycoside, e.g., β-methyl-D-galactoside, wherein the glycoside promotes the growth of beneficial endogenous bacteria and negatively affects the growth of endogenous pathogenic strains of bacteria. The disclosure also relates to methods of use, methods of screening, and methods of manufacture of said oral care compositions.
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8.发明公开PREBIOTIC ORAL CARE METHODS USING A SACCHARIDE 审中-公开PRÄBIOTISCHEMUNDPFLEGEVERFAHREN MIT EINEM SACCHARID
公开(公告)号：EP3086796A1
公开(公告)日：2016-11-02
申请号：EP13821399.6
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico
IPC分类号： A61K31/715 , A61K31/70 , A61K31/702 , A61K8/60 , A61Q11/00
CPC分类号： A61K8/60 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/463 , A61K8/73 , A61K8/731 , A61K8/8164 , A61K8/99 , A61K31/047 , A61K31/7008 , A61K31/702 , A61K31/7032 , A61K2800/28 , A61K2800/592 , A61Q11/00 , C12Q1/025 , G01N2500/10
摘要： The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myoinositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
摘要翻译： 本公开涉及增强有益的口腔细菌和减少有害的口腔细菌的方法，其包括给予包含益生糖的口腔护理组合物，例如选自D-萝糖糖，D-肉豆蔻，D-乳糖醇，肌醇和N-乙酰基-D- 甘露; 和用于这些方法的口腔护理组合物。 本公开还涉及使用益生元口腔护理组合物，筛选方法和制造方法的方法。
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公开(公告)号：EP3086801B1
公开(公告)日：2018-05-30
申请号：EP13821397.0
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico
IPC分类号： A61K38/05 , A61K8/64 , A61Q11/00 , A61K35/00 , A61K35/744 , A61K35/74 , A61K9/00 , A61K8/99 , A61K35/741
CPC分类号： A61K8/99 , A61K8/64 , A61K9/0063 , A61K35/74 , A61K35/741 , A61K35/744 , A61K38/05 , A61K2035/115 , A61K2800/74 , A61Q11/00 , A61K2300/00
摘要： The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.
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10.发明公开PREBIOTIC ORAL CARE COMPOSITIONS CONTAINING AMINO ACIDS 有权ÄE E E EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP3086801A1
公开(公告)日：2016-11-02
申请号：EP13821397.0
申请日：2013-12-27
发明人： STETTLER, Hans , TEUGHELS, Wim , QUIRYNEN, Marc , BOON, Nico
CPC分类号： A61K8/99 , A61K8/64 , A61K9/0063 , A61K35/74 , A61K35/741 , A61K35/744 , A61K38/05 , A61K2035/115 , A61K2800/74 , A61Q11/00 , A61K2300/00
摘要： The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.
摘要翻译： 本发明提供一种口腔护理组合物，其包含：（a）式Xaa1-Xaa2或Xaa2-Xaa1的二肽; 其中Xaa1是具有极性不带电侧链的氨基酸; Xaa2选自具有疏水侧链的氨基酸，具有极性不带电侧链的氨基酸和脯氨酸; 或（b）式Xaa3-Xaa4或Xaa4-Xaa3的二肽; 其中Xaa3是具有疏水侧链的氨基酸; 并且Xaa4选自具有疏水侧链的氨基酸和具有带电侧链的氨基酸。
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