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1.发明公开PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA 审中-公开PEPTIDE AUS GSE 24.2 ZUR BEHANDLUNG VON ERKRANKUNGEN INFOLGE VON OXIDATIVEM STRESS UND DNA-SCHADEN
公开(公告)号：EP3061815A1
公开(公告)日：2016-08-31
申请号：EP14856578.1
申请日：2014-10-24
申请人： Consejo Superior de Investigaciones Cientificas (CSIC) , Universidad Autónoma de Madrid , Advanced Medical Projects , Centro de Investigación Biomédica en Red (CIBER)
发明人： PERONA ABELLÓN, Rosario , SASTRE GARZÓN, Leandro , PINTADO BERNINCHES, Laura , CARRILLO GARCÍA, Jaime , MOLINA PACHÓN, Antonio , IRRADICCIO SILVA, Laura , MANGUAN GARCÍA, Cristina
CPC分类号： C12N9/1276 , A61K38/00 , C07K2319/09 , C12N9/90 , C12Y207/07049 , C12Y504/99
摘要： The invention relates to a polypeptide which comprises the fragment SEQ ID No.: 2 of the peptide GSE 24.2 (SEQ ID No.:1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide, such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
摘要翻译： 本发明涉及包含肽GSE 24.2（SEQ ID No.1）的SEQ ID No.2的片段的多肽，并且可以任选地减少游离基的产生和/或细胞的DNA结构的损伤 包括核定位序列。 本发明还涉及包含编码所述多肽的序列的多核苷酸和载体，以及包含所述多肽，多核苷酸和/或载体的药物组合物。 本发明还涉及多肽的应用，例如其用于治疗和/或预防由氧化应激增加和/或细胞DNA损伤引起的疾病，例如共济失调 - 毛细血管扩张症或先天性角化不全，或使用 在组织工程和细胞培养中增加其生存能力。
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2.发明公开PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA 审中-公开活性肽GSE 24.2疾病治疗的氧化应激引起的DNA损伤
公开(公告)号：EP3061815A9
公开(公告)日：2016-10-12
申请号：EP14856578.1
申请日：2014-10-24
申请人： Consejo Superior de Investigaciones Cientificas (CSIC) , Universidad Autónoma de Madrid , Advanced Medical Projects , Centro de Investigación Biomédica en Red (CIBER)
发明人： PERONA ABELLÓN, Rosario , SASTRE GARZÓN, Leandro , PINTADO BERNINCHES, Laura , CARRILLO GARCÍA, Jaime , MOLINA PACHÓN, Antonio , IRRADICCIO SILVA, Laura , MANGUAN GARCÍA, Cristina
CPC分类号： C12N9/1276 , A61K38/00 , C07K2319/09 , C12N9/90 , C12Y207/07049 , C12Y504/99
摘要： The invention relates to a polypeptide which comprises the fragment SEQ ID No.: 2 of the peptide GSE 24.2 (SEQ ID No.:1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide, such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
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3.发明授权
公开(公告)号：EP3061815B1
公开(公告)日：2020-02-19
申请号：EP14856578.1
申请日：2014-10-24
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Universidad Autónoma de Madrid , Advanced Medical Projects , Centro de Investigación Biomédica en Red (CIBER)
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