公开(公告)号：EP1709175A2

公开(公告)日：2006-10-11

申请号：EP04813083.5

申请日：2004-12-02

申请人： Corgentech, Inc.

发明人： MCEVOY, Leslie, M. ,  POWELL, Lyn ,  ZHANG, Jie ,  MORRIS, Karen

IPC分类号： C12N15/11 ,  A61K31/713 ,  A61P9/00 ,  A61P21/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2320/31

摘要： The invention concernes double-stranded HIF decoy oligodeoxynucleotide (dsODN) molecules comprising a core sequence that is capable of specific binding to a HIF transcription factor, compositions containing such molecules, and their use in the treatment of various diseases and pathologic conditions associated with the regulation of gene transcription by a HIF transcription factor.