公开(公告)号：EP1246900A4

公开(公告)日：2009-07-29

申请号：EP01901894

申请日：2001-01-09

申请人： CORGENTECH INC

发明人： MANN MICHAEL J ,  CHERKAS PAUL

IPC分类号： C12M3/00 ,  A61B17/00 ,  A61F2/00 ,  A61F2/06 ,  A61L27/00 ,  C12N5/06 ,  C12N5/10 ,  C12M1/00 ,  C12N15/00

CPC分类号： A61F2/062 ,  A61B2017/00252 ,  A61B2017/00969 ,  A61F2250/0067 ,  A61M2202/0445

公开(公告)号：EP1119389B1

公开(公告)日：2005-12-28

申请号：EP99953060.3

申请日：1999-10-05

申请人： Corgentech, Inc.

发明人： Mann, Michael J.

IPC分类号： A61M31/00

CPC分类号： A61M1/3687 ,  A61B90/39 ,  A61B2090/3954 ,  A61M1/3615 ,  A61M2025/0057

摘要： The invention relates to use of pulmonary catheters in methods for delivering a composition to the lung in a non-surgical, percutaneous approach by utilizing the pulmonary vasculature (i.e., the pulmonary arteries and veins). The invention also relates to methods allowing for the lung-specific delivery of a composition, as well as a catheter that includes a deployable arm.

公开(公告)号：EP1709175A2

公开(公告)日：2006-10-11

申请号：EP04813083.5

申请日：2004-12-02

申请人： Corgentech, Inc.

发明人： MCEVOY, Leslie, M. ,  POWELL, Lyn ,  ZHANG, Jie ,  MORRIS, Karen

IPC分类号： C12N15/11 ,  A61K31/713 ,  A61P9/00 ,  A61P21/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2320/31

摘要： The invention concernes double-stranded HIF decoy oligodeoxynucleotide (dsODN) molecules comprising a core sequence that is capable of specific binding to a HIF transcription factor, compositions containing such molecules, and their use in the treatment of various diseases and pathologic conditions associated with the regulation of gene transcription by a HIF transcription factor.

公开(公告)号：EP1098604A4

公开(公告)日：2004-07-21

申请号：EP99935605

申请日：1999-07-16

申请人： CORGENTECH INC

发明人： CORGENTECH INC

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61B19/00 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M25/007 ,  A61M2210/1071

摘要： In general, the invention features methods and apparatuses for delivering a composition to the liver in a non-surgical, percutaneous approach by utilizing the portal vein. Also disclosed are methods allowing for the liver-specific delivery of a composition.

公开(公告)号：EP1098604B1

公开(公告)日：2006-06-14

申请号：EP99935605.8

申请日：1999-07-16

申请人： Corgentech, Inc.

发明人： Mann, Michael

IPC分类号： A61B19/00 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M25/007 ,  A61M2210/1071

摘要： In general, the invention features methods and apparatuses for delivering a composition to the liver in a non-surgical, percutaneous approach by utilizing the portal vein. Also disclosed are methods allowing for the liver-specific delivery of a composition.

公开(公告)号：EP1608786A2

公开(公告)日：2005-12-28

申请号：EP04758363.8

申请日：2004-03-24

申请人： Corgentech, Inc.

发明人： ZHANG, Jie ,  WEI, Hsiu-Ying ,  MCEVOY, Leslie, Margaret

IPC分类号： C12Q1/68

CPC分类号： G06F19/18 ,  G06F19/22 ,  G06F19/28

摘要： A method is provided for profiling regulatory factor binding sites. A complete gene is located on genome for mapping gene regulatory regions. The genomic position of the most up-stream transcription start sites (TSS) of gene is identified. Genomic sequences of gene regulatory regions are defined and retrieved based on the identified TSS. DNA sequence information of each retrieved gene regulatory region is screened for identifying putative regulatory factor binding sites. The putative regulatory factor binding sites and their genomic occurrences are profiled.

公开(公告)号：EP1691817A2

公开(公告)日：2006-08-23

申请号：EP04813060.3

申请日：2004-12-02

申请人： Corgentech, Inc.

发明人： MCEVOY, Leslie, M. ,  PARHAM, Christi ,  ZHANG, Jie

IPC分类号： A61K31/70

CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

摘要： The present invention concerns double-stranded NF-KB decoy oligodeoxynucleotide (NF-KB dsODN) molecules that contain a core sequence capable of specific binding to an NF-KB transcription factor. In a particular aspect, the invention concerns NF-KB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-KB decoy molecules with improved binding affinity to p65.

公开(公告)号：EP1608785A2

公开(公告)日：2005-12-28

申请号：EP04758285.3

申请日：2004-03-24

申请人： Corgentech, Inc.

发明人： ZHANG, Jie ,  WEI, Hsiu-Ying ,  MCEVOY, Leslie, Margaret

IPC分类号： C12Q1/68

CPC分类号： G06F19/18 ,  G06F19/20 ,  G06F19/22 ,  Y02A90/26

摘要： The invention concerns the statistical analysis of regulatory factor binding sites of differentially expressed genes. More particularly, the invention concerns methods for identifying and characterizing regulatory factor, e.g. transcription factor binding sites in differentially expressed genes in order to develop therapeutic strategies for the treatment of diseases which are accompanied by differential gene expression, or to study biological processes.