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    DISRUPTED ADENOVIRUS-BASED VACCINE AGAINST DRUGS OF ABUSE
    3.
    发明公开
    DISRUPTED ADENOVIRUS-BASED VACCINE AGAINST DRUGS OF ABUSE 审中-公开
    UNTERBROCHENER IMPFSTOFF AUF ADENOVIRUSBASIS GEGEN DROGENMISSBRAUCH

    公开(公告)号：EP2547362A1

    公开(公告)日：2013-01-23

    申请号：EP11714876.7

    申请日：2011-03-17

    申请人： Cornell University

    发明人： CRYSTAL, Ronald G. ,  DE, Bishnu ,  HICKS, Martin ,  ROSENBERG, Jonathan ,  KAMINSKY, Stephen M.

    IPC分类号： A61K39/235 ,  A61K39/385

    CPC分类号： A61K39/0013 ,  A61K39/385 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/55511 ,  A61K2039/6075 ,  A61K2039/62 ,  C07K16/44 ,  C12N2710/10342

    摘要： The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.

    摘要翻译： 本发明涉及一种腺病毒 - 抗原结合物，其包含（a）具有外壳蛋白的破坏性腺病毒和（b）与破坏的腺病毒的外壳蛋白缀合的抗原，以及包含（a）破坏的腺病毒与 外壳蛋白和（b）与破坏的腺病毒的外壳蛋白缀合的抗原。 本发明还提供了使用上述缀合物诱导针对人抗原的免疫应答的方法。 本发明进一步提供了包含编码针对可卡因的抗体的核酸序列的腺相关病毒载体。

    ANGIOGENIC CONDITIONING TO ENHANCE CARDIAC CELLULAR REPROGRAMMING OF FIBROBLASTS OF THE INFARCTED MYOCARDIUM
    10.
    发明公开
    ANGIOGENIC CONDITIONING TO ENHANCE CARDIAC CELLULAR REPROGRAMMING OF FIBROBLASTS OF THE INFARCTED MYOCARDIUM 有权
    ANGIOGENE KONDITIONIERUNG ZUR VERBESSERUNG DER KARDIALEN ZELLREPROGRAMMIERUNG VON FIBROBLASTEN EINES INFARZIERTEN MYKARDS

    公开(公告)号：EP2914114A1

    公开(公告)日：2015-09-09

    申请号：EP13850199.4

    申请日：2013-11-01

    申请人： Cornell University ,  The Research Foundation for The State University of New York

    发明人： CRYSTAL, Ronald G. ,  ROSENGART, Todd K.

    IPC分类号： A01N63/00 ,  C12N5/00

    CPC分类号： A61K38/1866 ,  A61K38/00 ,  A61K38/1709 ,  A61K48/00 ,  A61K48/005 ,  C07K14/47 ,  C07K14/49 ,  C07K14/52 ,  C12N2710/10341 ,  C12N2740/15041

    摘要： Provided is a method of treating coronary artery disease in a mammal, comprising administering to a region of the heart of the mammal (a) a first vector encoding one or more angiogenic proteins which induce vascularization in the heart of the mammal, and (b) a second vector encoding one or more cardio-differentiating transcription factors which induce the production of induced cardiomyocytes (iCM) in the heart of the mammal, whereby the coronary artery disease in the mammal is treated. In a preferred embodiment, the first vector is an adenoviral vector encoding VEGF and the second vector is a lentiviral vector encoding Gata4, Mef2c, and Tbx5 (GMT).

    摘要翻译： 本发明提供一种治疗哺乳动物冠状动脉疾病的方法，包括给予哺乳动物心脏区域（a）编码在哺乳动物心脏中诱导血管形成的一种或多种血管生成蛋白质的第一载体，和（b） 编码一种或多种诱导在哺乳动物心脏中诱导的心肌细胞（iCM）产生的心脏分化的转录因子的第二载体，从而治疗哺乳动物的冠状动脉疾病。 在优选的实施方案中，第一载体是编码VEGF的腺病毒载体，第二载体是编码Gata4，Mef2c和Tbx5（GMT）的慢病毒载体。