公开(公告)号：EP2850194A2

公开(公告)日：2015-03-25

申请号：EP13790264.9

申请日：2013-05-17

申请人： The Trustees Of The University Of Pennsylvania

发明人： ROY, Soumitra ,  WILSON, James, M.

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  A61K35/761 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2740/16234

摘要： Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

摘要翻译： 重组载体包括猿猴腺病毒A1302（SADV-A1302，A1320-SADV，SADV-A1331，和/或SAdV-A1337序列和调控序列的控制下的异源基因。一种细胞系，快车哪个猿猴腺病毒SADV-A1302，SAdV- A1320，A1331-SADV，和/或SAdV-A1337基因IST游离缺失盘，并提供使用所述载体和细胞系的方法。

公开(公告)号：EP3368560A1

公开(公告)日：2018-09-05

申请号：EP16861065.7

申请日：2016-10-31

申请人： Spark Therapeutics, Inc.

发明人： ANGUELA, Xavier ,  SHEN, Sam Hsien-i

IPC分类号： C07K14/755 ,  C12N15/864 ,  C12P21/00

CPC分类号： C07K14/755 ,  A61K38/37 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0066 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

摘要： CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants encoding FVIII are expressed more efficiently by cells, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced expression and/or activity over wild-type Factor VIII proteins or are packaged more efficiently into viral vectors.

公开(公告)号：EP3197910A1

公开(公告)日：2017-08-02

申请号：EP15845254.0

申请日：2015-09-23

申请人： The Regents of the University of California

发明人： MRAZEK, Jan

IPC分类号： C07K14/47 ,  A61K47/50 ,  C12N15/12

CPC分类号： A61K9/5052 ,  A61K31/713 ,  A61K38/38 ,  C07K14/47 ,  C07K14/4702 ,  C12N7/00 ,  C12N2710/10323 ,  C12N2710/10342 ,  C12N2710/10351

摘要： Disclosed herein are methods of making vaults and packaging one or more passenger molecules in the internal cavities of the vault particles using cell-free techniques. Vaults according to the present invention and compositions comprising the vaults are free of cellular debris.

摘要翻译： 本文公开了使用无细胞技术制造拱顶和将穹窿体颗粒的内腔中的一个或多个乘客分子包装的方法。 根据本发明的拱顶和包含拱顶的组合物没有细胞碎片。

公开(公告)号：EP2850194A4

公开(公告)日：2016-06-08

申请号：EP13790264

申请日：2013-05-17

申请人： UNIV PENNSYLVANIA

发明人： ROY SOUMITRA ,  WILSON JAMES M

IPC分类号： C12N15/861 ,  C07K14/005 ,  C12N7/00

CPC分类号： C12N15/86 ,  A61K35/761 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2740/16234

摘要： Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

公开(公告)号：EP2774985A1

公开(公告)日：2014-09-10

申请号：EP14162957.6

申请日：2009-10-29

申请人： The Trustees of The University of Pennsylvania

发明人： Roy, Soumitra ,  Wilson, James M. ,  Vandenberghe, Luc H.

IPC分类号： C12N7/00 ,  C12N15/861

CPC分类号： C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10341 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/10352 ,  C12N2810/6018

摘要： A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

公开(公告)号：EP2350269A1

公开(公告)日：2011-08-03

申请号：EP09824127.6

申请日：2009-10-29

申请人： The Trustees Of The University Of Pennsylvania

发明人： ROY, Soumitra ,  WILSON, James, M. ,  VANDENBERGHE, Luc, H.

IPC分类号： C12N7/00 ,  C12N7/01

CPC分类号： C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10341 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/10352 ,  C12N2810/6018

摘要： A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

公开(公告)号：EP2558481B1

公开(公告)日：2017-12-20

申请号：EP10849873.4

申请日：2010-04-14

申请人： Mogam Biotechnology Research Institute

发明人： LEE, Kyuhyun ,  YUN, Seongtae ,  KOH, Daekyung ,  LEE, Hong-Kyu ,  JO, Eui-Cheol

IPC分类号： C07K14/075 ,  C12N15/34 ,  C12N15/861

CPC分类号： C12N7/00 ,  A61K39/0011 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/6018

摘要： Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.

公开(公告)号：EP2774985B1

公开(公告)日：2016-12-14

申请号：EP14162957.6

申请日：2009-10-29

申请人： The Trustees of The University of Pennsylvania

发明人： Roy, Soumitra ,  Wilson, James M. ,  Vandenberghe, Luc H.

IPC分类号： C12N7/00 ,  C12N15/861

CPC分类号： C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10341 ,  C12N2710/10342 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/10352 ,  C12N2810/6018

摘要： A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.

摘要翻译： 重组载体包含猿猴腺病毒43,45,46,47,48,49或50个序列，以及在调节序列控制下的异源基因。 还公开了表达猿腺病毒43,45,46,47,48,49或50个基因的细胞系。 提供了使用载体和细胞系的方法。

公开(公告)号：EP2547362A1

公开(公告)日：2013-01-23

申请号：EP11714876.7

申请日：2011-03-17

申请人： Cornell University

发明人： CRYSTAL, Ronald G. ,  DE, Bishnu ,  HICKS, Martin ,  ROSENBERG, Jonathan ,  KAMINSKY, Stephen M.

IPC分类号： A61K39/235 ,  A61K39/385

CPC分类号： A61K39/0013 ,  A61K39/385 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/55511 ,  A61K2039/6075 ,  A61K2039/62 ,  C07K16/44 ,  C12N2710/10342

摘要： The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.

摘要翻译： 本发明涉及一种腺病毒 - 抗原结合物，其包含（a）具有外壳蛋白的破坏性腺病毒和（b）与破坏的腺病毒的外壳蛋白缀合的抗原，以及包含（a）破坏的腺病毒与 外壳蛋白和（b）与破坏的腺病毒的外壳蛋白缀合的抗原。 本发明还提供了使用上述缀合物诱导针对人抗原的免疫应答的方法。 本发明进一步提供了包含编码针对可卡因的抗体的核酸序列的腺相关病毒载体。

公开(公告)号：EP1951883A2

公开(公告)日：2008-08-06

申请号：EP06838378.5

申请日：2006-11-21

申请人： Schering Corporation

发明人： LEE, Seoju ,  VELLEKAMP, Gary, J.

IPC分类号： C12N15/861

CPC分类号： C12N15/86 ,  C12N2710/10342

摘要： The present invention relates to improved methods for quantifying the degree of polymer attachment of particles with multiple polymer attachment sites. The disclosed methods are useful for gene therapy, particularly gene therapy using pegylated adenoviral vectors.