公开(公告)号：EP2279291A2

公开(公告)日：2011-02-02

申请号：EP09729677.6

申请日：2009-04-09

申请人： Cornell University ,  Purdue Research Foundation

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald ,  GARDINA, Sarah, Filippa

IPC分类号： C40B50/00 ,  C40B50/04

CPC分类号： A61K47/545 ,  A61K31/69 ,  C07D233/64 ,  C07D307/92 ,  C07D309/30 ,  C07D319/24 ,  C07D493/22 ,  C07F5/02 ,  C07H7/02 ,  C07H9/02 ,  C40B30/04

摘要： A monomer useful in prepa&pgr;ng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof.

公开(公告)号：EP2279291B1

公开(公告)日：2019-07-03

申请号：EP09729677.6

申请日：2009-04-09

申请人： Cornell University ,  Purdue Research Foundation

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald ,  GARDINA, Sarah, Filippa

IPC分类号： C40B50/00 ,  C40B50/04 ,  C07D233/64 ,  C07D307/92 ,  C07D309/30 ,  C07D319/24 ,  C07D493/22 ,  C07F5/02 ,  C07H7/02 ,  C07H9/02 ,  C40B30/04 ,  A61K47/54 ,  A61K31/69