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公开(公告)号：EP2694707B1
公开(公告)日：2018-08-15
申请号：EP12842368.8
申请日：2012-04-09
发明人： BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald E. , GIARDINA, Sarah, Filippa , ARNOLD, Lee, Daniel
IPC分类号： C07D409/06 , C07D491/107 , C07D211/26 , C07D405/06 , A61K31/422 , A61P29/00
CPC分类号： C07D211/26 , C07D405/06 , C07D409/06 , C07D491/107 , C07F5/025 , C07F5/04
摘要： Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
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公开(公告)号：EP2279291A2
公开(公告)日：2011-02-02
申请号：EP09729677.6
申请日：2009-04-09
CPC分类号： A61K47/545 , A61K31/69 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04
摘要： A monomer useful in prepa&pgr;ng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof.
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3.发明公开MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME 有权二聚化单体水溶液及其使用方法THEREOF
公开(公告)号：EP2694707A1
公开(公告)日：2014-02-12
申请号：EP12842368.8
申请日：2012-04-09
发明人： BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald E. , GIARDINA, Sarah, Filippa , ARNOLD,Lee, Daniel
CPC分类号： C07D211/26 , C07D405/06 , C07D409/06 , C07D491/107 , C07F5/025 , C07F5/04
摘要： Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
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4.发明授权
公开(公告)号：EP2693883B1
公开(公告)日：2018-12-26
申请号：EP12842488.4
申请日：2012-04-09
发明人： BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald E. , GIARDINA, Sarah, F. , ARNOLD, Lee, Daniel
CPC分类号： A61K31/695 , A61K47/55 , C07F7/10
摘要： Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
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5.发明公开
公开(公告)号：EP2693883A1
公开(公告)日：2014-02-12
申请号：EP12842488.4
申请日：2012-04-09
发明人： BARANY, Francis , PINGLE, Maneesh , BERGSTROM, Donald E. , GIARDINA, Sarah, F. , ARNOLD, Lee, Daniel
IPC分类号： A01N55/00 , A61K31/695
CPC分类号： A61K31/695 , A61K47/55 , C07F7/10
摘要： Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
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公开(公告)号：EP2279291B1
公开(公告)日：2019-07-03
申请号：EP09729677.6
申请日：2009-04-09
IPC分类号： C40B50/00 , C40B50/04 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04 , A61K47/54 , A61K31/69
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公开(公告)号：EP2485678A1
公开(公告)日：2012-08-15
申请号：EP10822356.1
申请日：2010-10-07
IPC分类号： A61F2/00
CPC分类号： C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/025 , C40B30/04
摘要： The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.
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8.发明授权HIGH FIDELITY DETECTION OF NUCLEIC ACID DIFFERENCES BY LIGASE DETECTION REACTION 失效NUCLEIC差异，通过连接酶检测反应的高灵敏度检测
公开(公告)号：EP0956359B1
公开(公告)日：2011-10-26
申请号：EP97936059.1
申请日：1997-07-15
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
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9.发明公开COUPLED POLYMERASE CHAIN REACTION-RESTRICTION ENDONUCLEASE DIGESTION-LIGASE DETECTION REACTION PROCESS 有权PROCEDURE ON聚合酶链反应的偶联反应（PCR）-VERDAUUNG用限制性酶和连接酶基于
公开(公告)号：EP1165838A2
公开(公告)日：2002-01-02
申请号：EP00918081.1
申请日：2000-03-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q1/6816 , C12Q1/6853 , C12Q2565/125 , C12Q2563/179 , C12Q2531/137 , C12Q2565/501 , C12Q2537/149 , C12Q2535/125 , C12Q2525/155
摘要： The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in a plurality of target nucleotide sequences. The high abundance wild-type sequence is selectively removed using high fidelity polymerase chain reaction analog conversion, facilitated by optimal buffer conditions, to create a restriction endonuclease site in the high abundance wild-type gene, but not in the low abundance mutant gene. This allows for digestion of the high abundance DNA. Subsequently the low abundant mutant DNA is amplified and detected by the ligase detection reaction assay. The present invention also relates to a kit for carrying out this procedure.
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10.发明授权COUPLED POLYMERASE CHAIN REACTION-RESTRICTION ENDONUCLEASE DIGESTION-LIGASE DETECTION REACTION PROCESS 有权PROCEDURE ON聚合酶链反应的偶联反应（PCR）-VERDAUUNG用限制性酶和连接酶基于
公开(公告)号：EP1165838B1
公开(公告)日：2006-10-11
申请号：EP00918081.1
申请日：2000-03-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , C12Q1/6816 , C12Q1/6853 , C12Q2565/125 , C12Q2563/179 , C12Q2531/137 , C12Q2565/501 , C12Q2537/149 , C12Q2535/125 , C12Q2525/155
摘要： The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in a plurality of target nucleotide sequences. The high abundance wild-type sequence is selectively removed using high fidelity polymerase chain reaction analog conversion, facilitated by optimal buffer conditions, to create a restriction endonuclease site in the high abundance wild-type gene, but not in the low abundance mutant gene. This allows for digestion of the high abundance DNA. Subsequently the low abundant mutant DNA is amplified and detected by the ligase detection reaction assay. The present invention also relates to a kit for carrying out this procedure.
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