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公开(公告)号：EP2118065A1
公开(公告)日：2009-11-18
申请号：EP07849684.1
申请日：2007-11-30
发明人： QAZI, Ghulam, Nabi , SAXENA, Ajit, Kumar , MUTHIAH, Shanmugavel , MONDHE, Dilip, Manikrao , SHARMA, Parduman, Raj , SINGH, Shashank, Kumar , SANYAL, Utpal , MUKHERJEE, Asama , HAZRA, Suva , DUTTA, Susanta
IPC分类号： C07D221/14 , A61K31/473 , A61P35/00
CPC分类号： C07D221/14
摘要： The present invention relates to novel substituted 1H-benz[de]isoquinoline-1,3-diones. This invention particularly relates to novel substituted 1H-benz[de]isoquinoline-1,3-diones particularly N-[2-(Chloroethyl)]- and N-[3-(Chloropropyl)]-naphthalimides and antitumor activity thereof. The present invention also relates to process of preparation of novel substituted 1H-benz[de]isoquinoline-1,3-diones. The present invention further relates to pharmaceutical composition for the treatment of cancer and related diseases.
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公开(公告)号：EP2118065B1
公开(公告)日：2013-08-14
申请号：EP07849684.1
申请日：2007-11-30
发明人： QAZI, Ghulam, Nabi , SAXENA, Ajit, Kumar , MUTHIAH, Shanmugavel , MONDHE, Dilip, Manikrao , SHARMA, Parduman, Raj , SINGH, Shashank, Kumar , SANYAL, Utpal , MUKHERJEE, Asama , HAZRA, Suva , DUTTA, Susanta
IPC分类号： C07D221/14 , A61K31/473 , A61P35/00
CPC分类号： C07D221/14
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3.发明授权A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES 有权用于生产光学活性的N-苄基-3- hydroxypyrrolidines
公开(公告)号：EP2361244B1
公开(公告)日：2013-07-10
申请号：EP09801288.3
申请日：2009-11-24
发明人： TANEJA, Subhash, Chandra , AGA, Mushtaq, Ahmad , KUMAR, Brijesh , SETHI, Vijay, Kumar , ANDOTRA, Samar, Singh , QAZI, Ghulam, Nabi
IPC分类号： C07D207/12
CPC分类号： C07D207/12
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4.发明公开A SYNERGISTIC HERBAL COMPOSITION FOR TREATMENT OF RHEUMATIC AND MUSCULO-SKELETAL DISORDERS (RMSDS) 有权协同作用的草药成分治疗风湿症和肌肉骨骼疾病（RMSD）
公开(公告)号：EP2175871A2
公开(公告)日：2010-04-21
申请号：EP08789918.3
申请日：2008-07-18
发明人： PATWARDHAN, Bhushan , CHOPRA, Arvind , NARSIMULU, Gumdal , HANDA, Rohini , BICHILE, Lata, S. , QAZI, Ghulam, Nabi , MUJUMDAR, Arvind, Manohar , SUMANTRAN, Venil, N. , PUSHPANGADAM, Palpu , MEHROTRA, Shanta , RAWAT, Ajay, Kumar, Singh , KHATOON, Sayyada , RASTOGI, Subha , RAGHAVAN, Govindarajan , RAUT, Ashwinikumar
IPC分类号： A61K36/9068 , A61K36/59 , A61K36/81 , A61K36/185 , A61K36/324 , A61P19/02
CPC分类号： A61K36/185 , A61K36/324 , A61K36/47 , A61K36/59 , A61K36/81 , A61K36/9068 , A61K2300/00
摘要： The present invention deals with a synergistic herbal composition useful for treatment of rheumatic and musculoskeletal disorders (RMSDs) comprising a base formulation (50-60 %) and plant parts and/or extracts of the plant (40-50 %) selected from the group consisting of Withania somnifera, Tribulus terrestris, Phyllanthus emblica and Boswellia serrata optionally along with pharmaceutically acceptable excipients. The herbal formulation is capable of causing simultaneous long term decrease in glycosaminoglycan (GAG) release and aggrecan by cartilage explants resulting in reduction of pain, inflammation, stiffness and low degeneration of bones, joints, muscles and other connective tissues. The present invention further deals with a process for the preparation of the said herbal formulation and a method of treating RMSDs using the formulation up to a high safety level and stable for a long durations.
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5.发明授权A SYNERGISTIC HERBAL COMPOSITION FOR TREATMENT OF RHEUMATIC AND MUSCULO-SKELETAL DISORDERS (RMSDS) 有权协同作用的草药成分治疗风湿症和肌肉骨骼疾病（RMSD）
公开(公告)号：EP2175871B1
公开(公告)日：2016-08-31
申请号：EP08789918.3
申请日：2008-07-18
发明人： PATWARDHAN, Bhushan , CHOPRA, Arvind , NARSIMULU, Gumdal , HANDA, Rohini , BICHILE, Lata, S. , QAZI, Ghulam, Nabi , MUJUMDAR, Arvind, Manohar , SUMANTRAN, Venil, N. , PUSHPANGADAM, Palpu , MEHROTRA, Shanta , RAWAT, Ajay, Kumar, Singh , KHATOON, Sayyada , RASTOGI, Subha , RAGHAVAN, Govindarajan , RAUT, Ashwinikumar
IPC分类号： A61K36/9068 , A61K36/59 , A61K36/81 , A61K36/185 , A61K36/324 , A61P19/02
CPC分类号： A61K36/185 , A61K36/324 , A61K36/47 , A61K36/59 , A61K36/81 , A61K36/9068 , A61K2300/00
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