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公开(公告)号：EP3183230B1
公开(公告)日：2018-10-24
申请号：EP15780946.8
申请日：2015-08-18
发明人： KAMAL, Ahmed , BAJEE, Shaik , REDDY, Challa Ratna , MALIK, Mohammed Shaheer , NAYAK, Vadithe Lakshma
IPC分类号： C07C233/29 , C07C235/38 , C07C237/20 , C07D209/18 , A61K31/404 , A61P35/00
CPC分类号： C07C235/38 , C07C231/02 , C07C233/29 , C07C237/20 , C07D209/18
摘要： The present invention provides a compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. [Formula should be entered here] General formula A where in B selected from aryl, heteroaryl and fused heteroaryl ring R and X selected from H, hydroxy, alkyl, alkoxy, prop-2-ynyloxy, allyloxy, halo, alkylhalides, alkoxy halides, nitro, amine.
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2.发明授权PYRROLO (2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF 有权吡咯并（2,1-C）（1,4）苯并二氮杂二聚体作为抗肿瘤剂和为此的方法
公开(公告)号：EP1608663B1
公开(公告)日：2008-11-05
申请号：EP03816507.2
申请日：2003-03-31
IPC分类号： C07D519/00 , A61K31/5517 , A61P35/00
CPC分类号： C07D519/00
摘要： The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the above analogs and a process of preparing these analogues.
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3.发明公开PYRROLO (2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF 有权吡咯并（2,1-C）（1,4）苯并二氮杂二聚体作为抗肿瘤剂和为此的方法
公开(公告)号：EP1608663A1
公开(公告)日：2005-12-28
申请号：EP03816507.2
申请日：2003-03-31
IPC分类号： C07D519/00 , A61K31/5517 , A61P35/00
CPC分类号： C07D519/00
摘要： The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the above analogs and a process of preparing these analogues.
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4.发明公开N-((3,4,5-TRIMETHOXYSTYRYL)ARYL)CINNAMAMIDE COMPOUNDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF 审中-公开N - （（3,4,5-三甲氧基苯乙烯基）芳基）CINNAMAMIDE化合物作为潜在的抗癌剂及其制备方法
公开(公告)号：EP3183230A1
公开(公告)日：2017-06-28
申请号：EP15780946.8
申请日：2015-08-18
发明人： KAMAL, Ahmed , BAJEE, Shaik , REDDY, Challa Ratna , MALIK, Mohammed Shaheer , NAYAK, Vadithe Lakshma
IPC分类号： C07C233/29 , C07C235/38 , C07C237/20 , C07D209/18 , A61K31/404 , A61P35/00
CPC分类号： C07C235/38 , C07C231/02 , C07C233/29 , C07C237/20 , C07D209/18
摘要： The present invention provides a compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. [Formula should be entered here] General formula A where in B selected from aryl, heteroaryl and fused heteroaryl ring R and X selected from H, hydroxy, alkyl, alkoxy, prop-2-ynyloxy, allyloxy, halo, alkylhalides, alkoxy halides, nitro, amine.
摘要翻译： 本发明提供了可用作针对人类癌细胞系的潜在抗癌剂的通式A的化合物及其制备方法。 通式A其中B选自芳基，杂芳基和稠合的杂芳基环R和X选自H，羟基，烷基，烷氧基，丙-2-炔氧基，烯丙氧基，卤素，烷基卤化物，烷氧基卤化物， 硝基，胺。
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5.发明授权PYRENE-LINKED PYRROLO(2,1-C)(1,4)BENZODIAZEPINE DERIVATIVES USEFUL AS ANTICANCER AGENTS 有权芘相关吡咯并（2,1-C）（1,4）用作抗癌剂苯并二氮杂衍生物
公开(公告)号：EP1608650B1
公开(公告)日：2010-06-02
申请号：EP03719078.2
申请日：2003-03-31
IPC分类号： C07D487/04 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to pyrrolo [2,1-c][1,4]benzodiazepine hybrids useful as potential antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, anticancer (antitumour) activity. The structural formula of this novel pyrrolo[2,1-c][1,4]benzodiazepine is given below, formula (I):
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6.发明公开
公开(公告)号：EP3405469A1
公开(公告)日：2018-11-28
申请号：EP17714569.5
申请日：2017-01-20
发明人： KAMAL, Ahmed , MANDA, Sathish , NARAYANA, Nagesh , NAGULA, Shankaraiah , SABANIS, Chetan Dushantrao , NAMBALLA, Hari Krishna
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： A compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation threof. General formula A R1 = 3-F, 3,4,5-OMe, 4-OMe, H, 4-CF3, 4-Cl, 4-OH-3-OMe, 3,4-CH2-O-CH2, 3,5-F, 4-OH, 1-napthyl, 9-phenanthryl, 4-Me. R2 = 3,4,5-OMe, 3,4-Cl, 4-F, 3,5-F, 2,5-OMe, 4-Cl, 4-OH-3-OMe, 3-OH, 3,4,5-OH, 4-CF3, 4-OMe, 4-NH2
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公开(公告)号：EP3039013B1
公开(公告)日：2018-09-12
申请号：EP13831914.0
申请日：2013-12-16
发明人： KAMAL, Ahmed , BASHA, Shaik Anver , KUMAR, Gajjela Bharath , REDDY, Vangala Santhosh , KUMAR, Chityal Ganesh
IPC分类号： C07D231/12 , A61K31/415 , A61P35/00
CPC分类号： C07D231/12 , C07D405/06 , C07D405/14
摘要： The present invention relates to a pyrazolochalcone of formula A useful as potential antitumor agent against human cancer cell lines and a process for the preparation thereof. Formula A wherein, R1, R2, R3, R4, R5=H, Cl, F, CH3, OCH3, 3,4(OCH2O) X=H, Cl, CH3, OCH3, 3,4(OCH2O), NH2, NO2, OH, dotted line indicates optionally cyclic structure.
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8.发明授权QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF 有权喹啉基取代的硫代内酯化合物及其制备方法
公开(公告)号：EP2566863B1
公开(公告)日：2014-05-14
申请号：EP11725801.2
申请日：2011-05-06
发明人： KAMAL, Ahmed , SHAIK, Azeeza , SHAIK, Ahmad, Ali , MALIK, Mohammed, Shaheer , KHAN, Inshad, Ali , ABDULLAH, Sheikh, Tasduq , SHARMA, Sandeep , RAM, Anshu, Beulah
IPC分类号： C07D409/14 , A61K31/4725 , A61P31/06
CPC分类号： C07D409/12 , C07D409/14
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9.发明公开QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF 有权喹啉基取代的硫代内酯化合物及其制备方法
公开(公告)号：EP2566863A1
公开(公告)日：2013-03-13
申请号：EP11725801.2
申请日：2011-05-06
发明人： KAMAL, Ahmed , SHAIK, Azeeza , SHAIK, Ahmad, Ali , MALIK, Mohammed, Shaheer , KHAN, Inshad, Ali , ABDULLAH, Sheikh, Tasduq , SHARMA, Sandeep , RAM, Anshu, Beulah
IPC分类号： C07D409/14 , A61K31/4725 , A61P31/06
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides compounds of general formulae A, useful as potential anti-tubercular agents against Mycobacterium tuberculosis H37Rv, and drug-resistant Mycobacterium tuberculosis and a process for the preparation thereof. Formula (A).
摘要翻译： 本发明提供了可用作针对结核分枝杆菌H37Rv的潜在抗结核剂和耐药结核分枝杆菌的通式A的化合物及其制备方法。 公式（A）。
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10.发明公开PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS 审中-公开PYRAZOLOCHALCONE ALS POTENZIELLE MITTEL GEGEN KREBS
公开(公告)号：EP3039013A1
公开(公告)日：2016-07-06
申请号：EP13831914.0
申请日：2013-12-16
发明人： KAMAL, Ahmed , BASHA, Shaik Anver , KUMAR, Gajjela Bharath , REDDY, Vangala Santhosh , KUMAR, Chityal Ganesh
IPC分类号： C07D231/12 , A61K31/415 , A61P35/00
CPC分类号： C07D231/12 , C07D405/06 , C07D405/14
摘要： The present invention relates to a pyrazolochalcone of formula A useful as potential antitumor agent against human cancer cell lines and a process for the preparation thereof. Formula A wherein, R1, R2, R3, R4, R5=H, Cl, F, CH3, OCH3, 3,4(OCH2O) X=H, Cl, CH3, OCH3, 3,4(OCH2O), NH2, NO2, OH, dotted line indicates optionally cyclic structure.
摘要翻译： 本发明涉及可用作人癌细胞系的潜在抗肿瘤剂的式A吡唑并己酸及其制备方法。 式A其中R1，R2，R3，R4，R5 = H，Cl，F，CH3，OCH3,3,4（OCH2O）X = H，Cl，CH3，OCH3,3,4（OCH2O），NH2， ，OH，虚线表示任选的环状结构。
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