公开(公告)号：EP3039010B1

公开(公告)日：2017-10-11

申请号：EP14786724.6

申请日：2014-08-29

申请人： Council of Scientific and Industrial Research

发明人： SANYAL, Sabyasachi ,  KUMAR, Atul ,  CHATTOPADHYAY, Naibedya ,  LAL, Jawahar ,  TRIVEDI, Arun Kumar ,  DATTA, Dipak ,  RATH, Srikanta Kumar ,  AKHTAR, Tahseen ,  DWIVEDI, Shailendra Kumar Dhar ,  YADAV, Manisha ,  CHAKRAVARTI, Bandana ,  SINGH, Abhishek Kumar ,  MISHRA, Jay Sharan ,  SINGH, Nidhi ,  TRIPATHI, Anil Kumar

IPC分类号： C07C251/48 ,  C07C251/58 ,  C07C251/60 ,  C07C319/02 ,  C07C321/26 ,  C07C249/08 ,  C07C55/07 ,  C07C57/15 ,  C07C59/255 ,  C07C59/265 ,  C07D295/088

CPC分类号： C07C251/48 ,  C07C55/07 ,  C07C57/15 ,  C07C59/255 ,  C07C59/265 ,  C07C249/08 ,  C07C251/58 ,  C07C251/60 ,  C07C319/02 ,  C07C321/26 ,  C07D295/088

摘要： The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.

公开(公告)号：EP3039010A1

公开(公告)日：2016-07-06

申请号：EP14786724.6

申请日：2014-08-29

申请人： Council of Scientific and Industrial Research

发明人： SANYAL, Sabyasachi ,  KUMAR, Atul ,  CHATTOPADHYAY, Naibedya ,  LAL, Jawahar ,  TRIVEDI, Arun Kumar ,  DATTA, Dipak ,  RATH, Srikanta Kumar ,  AKHTAR, Tahseen ,  DWIVEDI, Shailendra Kumar Dhar ,  YADAV, Manisha ,  CHAKRAVARTI, Bandana ,  SINGH, Abhishek Kumar ,  MISHRA, Jay Sharan ,  SINGH, Nidhi ,  TRIPATHI, Anil Kumar

IPC分类号： C07C251/48

CPC分类号： C07C251/48 ,  C07C55/07 ,  C07C57/15 ,  C07C59/255 ,  C07C59/265 ,  C07C249/08 ,  C07C251/58 ,  C07C251/60 ,  C07C319/02 ,  C07C321/26 ,  C07D295/088

摘要： The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.

摘要翻译： 本发明涉及通式（I）的取代的芳基萘基甲酮肟，其制备方法及其衍生物，盐，其药物组合物及其在治疗慢性骨髓性白血病，急性骨髓性白血病，淋巴瘤，多发性骨髓瘤，固体 作为有需要的受试者，包括诸如乳腺癌，子宫内膜癌结肠癌，前列腺癌和抗药性癌症干细胞的杀死的肿瘤形成细胞系。