公开(公告)号：EP3017307B1

公开(公告)日：2018-11-21

申请号：EP14739728.5

申请日：2014-07-04

申请人： Université de Strasbourg ,  Centre National de la Recherche Scientifique

发明人： WAGNER, Alain ,  KONIEV, Oleksandr

IPC分类号： G01N33/58 ,  G01N33/84 ,  C07K1/13 ,  C07C255/44 ,  C07C323/60 ,  C07D207/404 ,  C07C255/35 ,  C07C255/37 ,  C07C255/41 ,  C07C255/42 ,  C07F9/50

CPC分类号： C07C255/34 ,  C07B2200/05 ,  C07C255/35 ,  C07C255/37 ,  C07C255/41 ,  C07C255/42 ,  C07C255/43 ,  C07C255/44 ,  C07C271/16 ,  C07C271/22 ,  C07C271/28 ,  C07C275/42 ,  C07C309/42 ,  C07C319/02 ,  C07C323/42 ,  C07C323/60 ,  C07C331/28 ,  C07C335/22 ,  C07C2602/24 ,  C07D207/452 ,  C07D207/46 ,  C07D249/06 ,  C07D265/38 ,  C07D311/82 ,  C07D311/88 ,  C07D337/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D495/04 ,  C07F5/04 ,  C07F7/08 ,  C07F7/081 ,  C07F9/5442 ,  C07K1/13 ,  C07K14/70596 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  C07K19/00 ,  C07K2317/24 ,  C07K2317/76 ,  C12N9/2462 ,  C12Y302/01017 ,  G01N33/58 ,  G01N33/84

摘要： The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.

公开(公告)号：EP3380453A1

公开(公告)日：2018-10-03

申请号：EP16813183.7

申请日：2016-11-30

申请人： Chevron Phillips Chemical Company LP

发明人： HASENBERG, Daniel ,  PAUWELS, Alex

IPC分类号： C07C319/08 ,  C07C323/12 ,  B01J19/24

CPC分类号： C07C319/04 ,  B01J8/001 ,  B01J8/02 ,  B01J8/0292 ,  B01J2208/00513 ,  B01J2208/00548 ,  B01J2208/024 ,  B01J2208/025 ,  C07C319/02 ,  C07C319/08 ,  C07C323/12 ,  C07D303/02

摘要： A process includes reacting, in a reactor having a fixed bed containing a solid catalyst which contains a heterogeneous ion exchange resin, hydrogen sulfide and ethylene oxide in the presence of the solid catalyst to yield a reaction product which contains beta-mercaptoethanol. A reactor system includes the reactor, an ethylene oxide stream, a hydrogen sulfide stream, a fixed bed containing the solid catalyst placed in the reactor, and an effluent stream containing the reaction product. During steady state operation of the reactor in the process and the reactor system, the hydrogen sulfide and the ethylene oxide are present in a mole ratio in a range of about 9:1 to about 20:1.

公开(公告)号：EP2456756B1

公开(公告)日：2017-06-14

申请号：EP10734978.9

申请日：2010-07-16

申请人： Evonik Degussa GmbH

发明人： BARTH, Jan-Olaf ,  WECKBECKER, Christoph ,  REDLINGSHÖFER, Hubert ,  LERCHER, Johannes A. ,  KAUFMANN, Christoph

IPC分类号： C07C319/02 ,  C07C319/28 ,  C07C321/04 ,  C01B17/16

CPC分类号： C07C319/02 ,  C01B17/161 ,  C07C319/08 ,  Y02P20/127 ,  Y02P20/582 ,  C07C321/04

公开(公告)号：EP3030635A1

公开(公告)日：2016-06-15

申请号：EP14833997.1

申请日：2014-08-06

申请人： The Scripps Research Institute ,  Periana, Roy A. ,  Konnick, Michael M. ,  Hashiguchi, Brian G.

发明人： PERIANA, Roy A. ,  KONNICK, Michael M. ,  HASHIGUCHI, Brian G.

IPC分类号： C10L1/24

CPC分类号： C07C395/00 ,  C07B39/00 ,  C07B41/06 ,  C07B43/04 ,  C07B45/00 ,  C07B47/00 ,  C07C1/321 ,  C07C17/093 ,  C07C45/00 ,  C07C209/22 ,  C07C231/10 ,  C07C319/02 ,  C07C319/14 ,  C07C391/00 ,  C07F7/2208 ,  C07F9/5004 ,  C07C321/04 ,  C07C321/14 ,  C07C11/02

摘要： The invention provides processes and materials for the efficient and costeffective functionalization of alkanes and heteroalkanes, comprising contacting the alkane or heteroalkane and a soft oxidizing electrophile comprising Se(VI) or Te(VI), in an acidic medium, optionally further comprising an aprotic medium, which can be carried out at a temperature of less than 300C. Isolation of the alkylselenium or alkyltellurium intermediate allows the subsequent conversion to products not necessarily compatible with the initial reaction conditions, such as amines, stannanes, organosulfur compounds, acyls, halocarbons, and olefins.

摘要翻译： 本发明提供了用于烷烃和杂烷烃的有效且高效功能化的方法和材料，包括在酸性介质中使烷烃或杂烷烃与包含Se（VI）或Te（VI）的软氧化亲电子试剂接触，任选还包含非质子介质 这可以在低于30℃的温度下进行。 烷基硒或烷基碲中间体的分离允许随后转化成与初始反应条件不一定相容的产物，例如胺，锡烷，有机硫化合物，酰基，卤化碳和烯烃。

公开(公告)号：EP2978525A1

公开(公告)日：2016-02-03

申请号：EP14713142.9

申请日：2014-03-28

申请人： Arkema France

发明人： FREMY, Georges ,  BARRE, Patrice ,  SANCHOU, Karine ,  CORDOVA, Alexia ,  LAMONIER, Carole ,  BLANCHARD, Pascal

IPC分类号： B01J23/28 ,  B01J23/04 ,  B01J32/00 ,  B01J23/887 ,  B01J27/18 ,  C07C319/02 ,  C07C321/04 ,  B01J37/20 ,  B01J37/02

CPC分类号： C07C319/02 ,  B01J23/28 ,  B01J23/745 ,  B01J23/755 ,  B01J27/051 ,  B01J27/0576 ,  B01J27/1806 ,  B01J35/0006 ,  B01J35/1014 ,  B01J37/0201 ,  B01J37/0207 ,  C07C319/06 ,  C07C321/04

摘要： The invention relates to a catalyst comprising an active component based on molybdenum and on potassium and a support based on hydroxyapatite, and also to a process for preparing said catalyst and a process for producing methyl mercaptan in a catalytic process by reaction of carbon monoxide, sulphur and/or hydrogen sulphide and hydrogen, comprising the use of said catalyst.

公开(公告)号：EP2687520A4

公开(公告)日：2014-08-13

申请号：EP12760759

申请日：2012-02-28

申请人： SUMITOMO SEIKA CHEMICALS

发明人： KANDA HISAAKI ,  KONISHI HIROTSUGU ,  YAMAGUCHI HIROKI

IPC分类号： C07D275/04 ,  B01J31/02 ,  C07B61/00 ,  C07C319/14 ,  C07C323/62

CPC分类号： C07D275/04 ,  C07C319/02 ,  C07C319/12 ,  C07C319/14 ,  Y02P20/582 ,  C07C323/62 ,  C07C321/04

公开(公告)号：EP0780372B3

公开(公告)日：2013-05-22

申请号：EP96810865.4

申请日：1996-12-12

申请人： Syngenta Participations AG

发明人： Kunz, Walter ,  Jau, Beat

IPC分类号： C07C323/63 ,  C07C327/26 ,  C07D277/82 ,  C07C335/22 ,  C07D285/14

CPC分类号： C07D285/14 ,  C07C319/02 ,  C07C319/12 ,  C07C323/63 ,  C07C327/26 ,  C07C335/22 ,  C07D277/82

公开(公告)号：EP2509933A1

公开(公告)日：2012-10-17

申请号：EP10787133.7

申请日：2010-12-07

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： CONNON, Stephen Joseph ,  PESCHIULLI, Aldo ,  PROCURANTI, Barbara

IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C227/32 ,  C07C229/08 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C321/10 ,  C07C323/07 ,  C07C323/16 ,  C07C327/22 ,  C07C327/28 ,  C07D453/04

CPC分类号： C07C327/22 ,  C07B57/00 ,  C07B2200/07 ,  C07C51/083 ,  C07C227/32 ,  C07C231/18 ,  C07C233/05 ,  C07C319/02 ,  C07C319/12 ,  C07C319/28 ,  C07C321/18 ,  C07C327/28 ,  C07D453/04 ,  C07C321/10 ,  C07C229/08 ,  C07C323/16 ,  C07C323/07

摘要： Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols ( i . e ., R-SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

公开(公告)号：EP1436256B1

公开(公告)日：2011-08-10

申请号：EP02765080.3

申请日：2002-10-03

申请人： AstraZeneca AB

发明人： WARREN, Kenneth, Edwin, Herbert ,  KANE, Anne, Margaret, Lamont

IPC分类号： C07C319/20 ,  C07C323/03 ,  C07C335/08

CPC分类号： C07C319/02 ,  C07C303/28 ,  C07C319/14 ,  C07C319/20 ,  C07C323/12 ,  C07C335/32 ,  C07C323/03 ,  C07C309/66

摘要： A process for preparing an intermediate compound of formula (II) where n is an integer of from 3 to 14; R1 is haloC¿1-10?alkyl, C1-10alkyl, C2-10alkenyl, C2-10cycloalkyl, carboxyC1-10alkyl, C1-10alkoxycarbonylC1-10alkyl, aryl (such as phenyl), aryl(C1-10)alkyl (such as phenyl(C1-10)alkyl) or di(C1-6alkyl)amino; and R?2¿ is a halo group; the process comprising halogenation of a compound of formula (III) where n and R1 are as defined above. The compounds of formulae (IIIA, IIIB, IV) and derivatives are also claimed.

公开(公告)号：EP1686114B1

公开(公告)日：2009-10-07

申请号：EP04818942.7

申请日：2004-11-18

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： HIGUCHI, Yasushi; c/o Japan Hydrazine Co,Inc. ,  TANAKA, Akinori; c/o Mitsubishi Gas Chemical Co., ,  HASEMI, Ryuji; c/o Mitsubishi Gas Chemical Co., In ,  SUGITA, Masaki;2c/o Mitsubishi Gas Chemical Co., I

IPC分类号： C07C319/02 ,  C07C323/58 ,  C07D277/06 ,  C07B53/00 ,  C07B57/00 ,  C12P13/12 ,  C12P41/00

CPC分类号： C12P13/12 ,  C07B2200/07 ,  C07C319/02 ,  C07D277/06 ,  C07D277/60 ,  C07C323/58

摘要： A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively hydrolyze the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof, to act on a mixture of the D and L isomers of either a 2-alkylcysteinamide or a salt thereof and then reacting the resultant 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide with an aldehyde, a ketone, or an acetal or ketal of either to yield a 4-alkylthiazolidine-4-carboxylic acid or salt thereof and a 4-alkylthiazolidine-4-carboxamide or salt thereof and thereby efficiently isolate either of the 2-alkyl-L-cysteine or salt thereof and the 2-alkyl-D-cysteine or salt thereof. Also provided is a process for producing a 4-alkylthiazolidine-4-carboxylic acid or salt thereof from a 2-alkylcysteine or salt thereof.