公开(公告)号：EP2405742A2

公开(公告)日：2012-01-18

申请号：EP10708868.4

申请日：2010-03-11

申请人： CryoLife, Inc.

发明人： WALSH, Steven ,  HAMBY, Joseph ,  CHINICH, Chad

IPC分类号： A01N1/02 ,  C12N5/00

CPC分类号： A01N1/0215

摘要： An antibiotic composition is provided for use in decontaminating biological tissue. For example, graft tissues for transplantation or preparation For terminal sterilization. The antibiotic composition is a physiological solution includes a antibiotic, such as nisin. The antibiotic solution is effective to substantially inhibit bacterial growth of at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue. The method may include contacting the tissue with the antimicrobial composition at a temperature and for a period of time effective to substantially inhibit bacterial growth of the at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue.