公开(公告)号：EP1569511A1

公开(公告)日：2005-09-07

申请号：EP03813016.7

申请日：2003-12-11

申请人： CryoLife, Inc.

发明人： GOLDSTEIN, Steven ,  HAMBY, Joseph ,  WALSH, Steven, P. ,  BLACK, Kirby, S.

IPC分类号： A01N1/02

CPC分类号： A01N1/0215 ,  A01N1/02

摘要： A novel solution for cryopreservation of a tissue that includes water, a bio­compatible buffer, a cell-impermeant constituent, a cell-permeant constituent, and a radical scavenger is disclosed. The solution may be used to preserve the tissue for later transplantation in an animal, including human, host. The radical scavenger is believed to reduce damage to the tissue that could otherwise occur during sterilization with ionizing radiation.

摘要翻译： 公开了用于冷冻包含水，生物相容性缓冲液，细胞渗透性成分，细胞渗透性成分和自由基清除剂的组织的新型溶液。 可以使用该溶液来保存组织，以便随后在包括人，宿主的动物中移植。 据信自由基清除剂可减少在用电离辐射灭菌期间可能发生的组织损伤。

公开(公告)号：EP2405742A2

公开(公告)日：2012-01-18

申请号：EP10708868.4

申请日：2010-03-11

申请人： CryoLife, Inc.

发明人： WALSH, Steven ,  HAMBY, Joseph ,  CHINICH, Chad

IPC分类号： A01N1/02 ,  C12N5/00

CPC分类号： A01N1/0215

摘要： An antibiotic composition is provided for use in decontaminating biological tissue. For example, graft tissues for transplantation or preparation For terminal sterilization. The antibiotic composition is a physiological solution includes a antibiotic, such as nisin. The antibiotic solution is effective to substantially inhibit bacterial growth of at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue. The method may include contacting the tissue with the antimicrobial composition at a temperature and for a period of time effective to substantially inhibit bacterial growth of the at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue.