公开(公告)号：EP2188295A2

公开(公告)日：2010-05-26

申请号：EP08831492.7

申请日：2008-08-08

申请人： Crystalgenomics, Inc.

发明人： KIM, Sun, Nam ,  HONG, Yong, Rae ,  SHIN, Dongkyu ,  RO, Seonggu ,  CHO, Joong, Myung ,  LEE, Mi Jung ,  CHANG, Ho, Jin

IPC分类号： C07D495/04 ,  C07D491/048 ,  C07D471/04

CPC分类号： C07D495/04 ,  C07D471/04 ,  C07D491/048

摘要： Disclosed herein are pyridine derivatives, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, pharmaceutical compositions comprising the same, and methods of modulating the level or activity of HIF in a subject, inhibiting hydroxylation of HIF α in a subject, modulating expression of HIF -regulated genes in a subject, treating an HIF-related disorder in a subject, increasing levels of endogenous EPO in a subject, or treating a disorder in a subject, using the disclosed compounds.