公开(公告)号：EP1973885A1

公开(公告)日：2008-10-01

申请号：EP06835365.5

申请日：2006-12-22

申请人： Crystalgenomics, Inc.

发明人： PARK, Boonsaeng ,  LEE, Mi Jung ,  SONG, Yu-Mi ,  LEE, Do Young ,  LEE, Seung Chul ,  KIM, Cheol Min ,  RO, Seonggu ,  CHO, Joong Myung

IPC分类号： C07D239/42 ,  A61P3/00 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12

摘要： A compound of formula 1 efficiently inhibit several protein kinases including glycogen synthase kinase 3 (GSK), aurora kinase, extracellular signal- regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions involved in variable disorders such as diabetes, obesity, dementia, cancer, and inflammation.

公开(公告)号：EP2188295A2

公开(公告)日：2010-05-26

申请号：EP08831492.7

申请日：2008-08-08

申请人： Crystalgenomics, Inc.

发明人： KIM, Sun, Nam ,  HONG, Yong, Rae ,  SHIN, Dongkyu ,  RO, Seonggu ,  CHO, Joong, Myung ,  LEE, Mi Jung ,  CHANG, Ho, Jin

IPC分类号： C07D495/04 ,  C07D491/048 ,  C07D471/04

CPC分类号： C07D495/04 ,  C07D471/04 ,  C07D491/048

摘要： Disclosed herein are pyridine derivatives, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, pharmaceutical compositions comprising the same, and methods of modulating the level or activity of HIF in a subject, inhibiting hydroxylation of HIF α in a subject, modulating expression of HIF -regulated genes in a subject, treating an HIF-related disorder in a subject, increasing levels of endogenous EPO in a subject, or treating a disorder in a subject, using the disclosed compounds.