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公开(公告)号：EP3215161A1
公开(公告)日：2017-09-13
申请号：EP15817308.8
申请日：2015-12-21
申请人： Curadis GmbH
发明人： UNTEREGGER, Gerhard
IPC分类号： A61K31/5685 , A61P35/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/02 , A61P19/02 , A61P27/02 , A61P3/04 , A61P1/04
CPC分类号： A61K31/5685 , A61K2300/00
摘要： The present invention relates to the field of medicine, particularly to novel uses of C-19 steroid compounds having an androsten-17-(OR
4 )-3-one structure for inhibiting angiogenesis and particularly the proliferation and/or migration of endothelial cells in the treatment of diseases involving a pathological neovascularization and/or excessive regenerative processes.摘要翻译： 本发明涉及医学领域，具体涉及具有雄甾-17-（OR 4）-3-酮结构的C-19类固醇化合物用于抑制血管生成，特别是内皮细胞增殖和/或迁移的新用途， 涉及病理性新血管形成和/或过度再生过程的疾病的治疗。
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公开(公告)号：EP3836937A1
公开(公告)日：2021-06-23
申请号：EP19783507.7
申请日：2019-10-04
申请人： Curadis GmbH
IPC分类号： A61K31/568 , A61K45/06 , A61P35/00 , A61K31/337 , A61K31/519 , A61K31/565 , A61K31/138 , A61K31/277 , A61K31/4166 , A61K31/5685 , A61K31/58
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公开(公告)号：EP3632445A1
公开(公告)日：2020-04-08
申请号：EP18198631.6
申请日：2018-10-04
申请人： Curadis GmbH
IPC分类号： A61K31/568 , A61K45/06 , A61P35/00 , A61K31/337 , A61K31/519 , A61K31/565 , A61K31/138 , A61K31/277 , A61K31/4166 , A61K31/5685 , A61K31/58
摘要： The present invention relates to the field of medicine, particularly to novel uses of C-19 steroid compounds, more particularly to C-19 steroids having an androsten-3-one structure with specific structural configurations, in particular at the 4- and/or 17-position, for inhibition of cancer cell growth in combination with another anticancer agent or as second or third line treatment. The present invention particularly relates to selected C-19 steroids inhibiting the proliferation of tumor cells expressing an androgen receptor and show only limited sensitivity to other cancer agents such as aromatase inhibitors, androgen receptor antagonists, androgen synthesis inhibitors, chemotherapeutics as well as CDK4/CDK6 inhibitors.
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