公开(公告)号：EP2305716A2

公开(公告)日：2011-04-06

申请号：EP10172437.5

申请日：2005-11-30

申请人： Curagen Corporation ,  Abgenix, Inc.

发明人： Rastelli, Luca ,  Pollack, Vincent A ,  Tse, Kam Fai ,  Klakamp, Scott ,  Foord, Orit ,  Liang, Meina ,  Xiao, Feng ,  Lichensten, Henri ,  Herrmann, John ,  Larochelle, William J. ,  Jeffers, Michael E. ,  Chapoval, Andrei ,  Mezes, Peter ,  Ara, Gulshan ,  Torgov, Michael ,  Karkaria, Cyrus ,  Davagnino, Juan ,  Jia, Xiao-Chi

IPC分类号： C07K16/30

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human lonoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. the present invention futher provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.

摘要翻译： 本发明提供了完全与GPNMB结合的人类单克隆抗体及其用途。 提供编码核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。 本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。 本发明还提供了包含抗GPNMB抗体组分和抗CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

公开(公告)号：EP2305716A3

公开(公告)日：2011-05-25

申请号：EP10172437.5

申请日：2005-11-30

申请人： Curagen Corporation ,  Abgenix, Inc.

发明人： Rastelli, Luca ,  Pollack, Vincent A ,  Tse, Kam Fai ,  Klakamp, Scott ,  Foord, Orit ,  Liang, Meina ,  Xiao, Feng ,  Lichensten, Henri ,  Herrmann, John ,  Larochelle, William J. ,  Jeffers, Michael E. ,  Chapoval, Andrei ,  Mezes, Peter ,  Ara, Gulshan ,  Torgov, Michael ,  Karkaria, Cyrus ,  Davagnino, Juan ,  Jia, Xiao-Chi

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  G01N33/574 ,  G01N33/577

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human lonoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. the present invention futher provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.