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公开(公告)号：EP1334126A1
公开(公告)日：2003-08-13
申请号：EP01274016.3
申请日：2001-03-23
发明人： RASTELLI, Luca, K. , PENNICA, Diane
IPC分类号： C07K14/475 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： An isolated human STRA6 (stimulated by retinoic acid) polypeptide comprising an amino acid sequence having at least 80 % sequence identity to one or both of SEQ ID NOS: 2 or 4, polynucleotides encoding these polypeptides, and antibodies to the polypeptides are useful in treating cancers.
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公开(公告)号：EP1265920B9
公开(公告)日：2007-01-24
申请号：EP01922679.4
申请日：2001-03-22
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075
摘要： An isolated polypeptide having at least 80 % sequence identity to the sequence SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.
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公开(公告)号：EP1265920A2
公开(公告)日：2002-12-18
申请号：EP01922679.4
申请日：2001-03-22
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075
摘要： An isolated polypeptide having at least 80 % sequence identity to the sequence SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.
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公开(公告)号：EP1265920B1
公开(公告)日：2006-11-08
申请号：EP01922679.4
申请日：2001-03-22
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075
摘要： An isolated polypeptide having at least 80 % sequence identity to the sequence SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.
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公开(公告)号：EP1290005A2
公开(公告)日：2003-03-12
申请号：EP01924240.3
申请日：2001-03-21
摘要： The present invention provides methods for modulating angiogenesis and/or apoptosis comprising modulating the activity of at least one VEGF-modulated gene polypeptide. The invention also provides pharmaceutical compositions for modulating angiogenesis and apoptosis for the prevention or treatment of diseases associated with VEGF-modulated genes expression. The invention also provides diagnostic assays that use VEGF-modulated gene polynucleotides that hybridize with naturally occurring sequences encoding VEGF-modulated genes and antibodies that specifically bind to the protein. The invention also provides novel human and mouse arginine-rich proteins (ARPs) and nucleotide sequences. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding ARPs and for a method for producing the protein.
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公开(公告)号：EP1265914B1
公开(公告)日：2007-12-26
申请号：EP01920759.6
申请日：2001-03-22
发明人： RASTELLI, Luca, K. , PENNICA, Diane
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K48/00
摘要： An isolated polypeptide comprising an amino acid sequence having at least 80 % sequence identity to the sequence of SEQ ID NOS: 1, 3, 5, or 7 polynucleotides encoding these peptides, and antibodies to the polypeptides are useful in treating cancers.
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公开(公告)号：EP1265914A2
公开(公告)日：2002-12-18
申请号：EP01920759.6
申请日：2001-03-22
发明人： RASTELLI, Luca, K. , PENNICA, Diane
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K48/00
摘要： An isolated Wnt-1 related polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence of SEQ ID NOS: 1, 3, 5, or 7 polynucleotides encoding these peptides,and antibodies to the polypeptides are useful in treating cancers
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