公开(公告)号：EP1083232B1

公开(公告)日：2005-02-23

申请号：EP99117771.8

申请日：1999-09-09

申请人： CureVac GmbH

发明人： Jung, Günther, Prof.Dr. ,  Hoerr, Ingmar ,  Rammensee, Hans-Georg, Prof.Dr. ,  Obst, Reinhard, Dr.

IPC分类号： C12N15/87 ,  A61K48/00 ,  A61K38/00 ,  A61P31/12

CPC分类号： A61K9/0019 ,  A61K9/1272 ,  A61K48/00 ,  A61K2039/53 ,  C12N15/87 ,  Y02A50/412

摘要： The invention provides a method for the transfer of RNA, especially mRNA, into cells and into organisms. This method is especially suited for applications in the field of gene therapy. The RNA is transferred in the form of a complex between at least one RNA and at least one cationic, especially polycationic, peptide or protein. Preferably protamine, poly-L-lysine and/or histone is used as cationic peptide or protein.