公开(公告)号：EP1897559A1

公开(公告)日：2008-03-12

申请号：EP07017925.4

申请日：2000-01-11

申请人： CyDex, Inc.

发明人： Stella, Valentino J. ,  Rajewski, Roger A. ,  Rao, Venkatramana M. ,  Mc Ginity, James W. ,  Mosher, Gerold L.

IPC分类号： A61K47/40 ,  A61K9/20 ,  A61K9/28

CPC分类号： B82Y5/00 ,  A61K9/205 ,  A61K9/2059 ,  A61K9/209 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/4808 ,  A61K47/40 ,  A61K47/6951 ,  Y10S514/964 ,  Y10S514/965

摘要： A controlled release solid pharmaceutical formulation comprising:
a core comprising a first composition comprising a physical mixture of a therapeutic agent and at least one sulfoalkyl ether cyclodextrin, wherein a major portion of the therapeutic agent is not complexed with the sulfoalkyl ether cyclodextrin; and
a coating surrounding said core and consisting of a film forming agent;
wherein, said therapeutic agent of the first composition is released from the core at a controlled rate in the absence of a pore forming agent in the coating.

摘要翻译： 一种控释固体药物制剂，其包含：包含第一组合物的核心，所述第一组合物包含治疗剂和至少一种磺基烷基醚环糊精的物理混合物，其中所述治疗剂的主要部分与所述磺基烷基醚环糊精不络合; 以及围绕所述芯并由成膜剂组成的涂层; 其中，所述第一组合物的所述治疗剂在所述涂层中不存在成孔剂时以受控的速率从所述芯释放。

公开(公告)号：EP1897560A1

公开(公告)日：2008-03-12

申请号：EP07017926.2

申请日：2000-01-11

申请人： CyDex, Inc.

发明人： Stella, Valentino J. ,  Rajewski, Roger A. ,  Rao, Venkatramana M. ,  Mc Ginity, James W. ,  Mosher, Gerold L.

IPC分类号： A61K47/40 ,  A61K9/20 ,  A61K9/28

CPC分类号： B82Y5/00 ,  A61K9/205 ,  A61K9/2059 ,  A61K9/209 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/4808 ,  A61K47/40 ,  A61K47/6951 ,  Y10S514/964 ,  Y10S514/965

摘要： An osmotic solid pharmaceutical formulation for the controlled diffusional and osmotic delivery of a therapeutic agent to an environment of use comprising:
a core comprising a physical mixture of a sulfoalkyl ether cyclodextrin, a therapeutic agent and a pharmaceutically acceptable carrier; and
a membrane surrounding said core and comprising a film forming agent and a pore forming agent, said membrane having a passageway therethrough for communicating said core to an environment of use;
wherein,
a first portion of said therapeutic agent diffuses through said membrane and a second portion of said therapeutic agent passes through said passageway; and
a major portion of said therapeutic agent is not complexed with said sulfoalkyl ether cyclodextrin.

摘要翻译： 一种用于将治疗剂控制扩散和渗透递送至使用环境的渗透固体药物制剂，其包含：包含磺基烷基醚环糊精，治疗剂和药学上可接受的载体的物理混合物的核心; 以及围绕所述芯并包含成膜剂和成孔剂的膜，所述膜具有通过其的通道，用于将所述芯连通到使用环境; 其中，所述治疗剂的第一部分通过所述膜扩散，并且所述治疗剂的第二部分通过所述通道; 并且所述治疗剂的主要部分与所述磺基烷基醚环糊精不复合。

公开(公告)号：EP1859790A3

公开(公告)日：2008-03-05

申请号：EP07017927.0

申请日：2000-01-11

申请人： CyDex, Inc.

发明人： Stella, Valentino J. ,  Rajewski, Roger A. ,  Rao, Venkatramana M. ,  Mc Ginity, James W. ,  Mosher, Gerold L.

IPC分类号： A61K47/40 ,  A61K9/20 ,  A61K9/28

CPC分类号： B82Y5/00 ,  A61K9/205 ,  A61K9/2059 ,  A61K9/209 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/4808 ,  A61K47/40 ,  A61K47/6951 ,  Y10S514/964 ,  Y10S514/965

摘要： A multi-layered combined rapid and controlled release solid pharmaceutical formulation comprising:
at least one controlled release first layer comprising a physical mixture of a first therapeutic agent, a release rate modifier and a sulfoalkyl ether cyclodextrin for releasing said first therapeutic agent at a controlled rate into a first environment of use; and
at least one rapid release second layer comprising a physical mixture of a second therapeutic agent and a sulfoalkyl ether cyclodextrin for releasing said second therapeutic agent rapidly into a second environment of use;
wherein,
said first and second layers are juxtaposed; and
major portions of each of said first and second therapeutic agents are not complexed with said sulfoalkyl ether cyclodextrin.

公开(公告)号：EP1859790A2

公开(公告)日：2007-11-28

申请号：EP07017927.0

申请日：2000-01-11

申请人： CyDex, Inc.

发明人： Stella, Valentino J. ,  Rajewski, Roger A. ,  Rao, Venkatramana M. ,  Mc Ginity, James W. ,  Mosher, Gerold L.

IPC分类号： A61K9/22

CPC分类号： B82Y5/00 ,  A61K9/205 ,  A61K9/2059 ,  A61K9/209 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/4808 ,  A61K47/40 ,  A61K47/6951 ,  Y10S514/964 ,  Y10S514/965

摘要： A multi-layered combined rapid and controlled release solid pharmaceutical formulation comprising:
at least one controlled release first layer comprising a physical mixture of a first therapeutic agent, a release rate modifier and a sulfoalkyl ether cyclodextrin for releasing said first therapeutic agent at a controlled rate into a first environment of use; and
at least one rapid release second layer comprising a physical mixture of a second therapeutic agent and a sulfoalkyl ether cyclodextrin for releasing said second therapeutic agent rapidly into a second environment of use;
wherein,
said first and second layers are juxtaposed; and
major portions of each of said first and second therapeutic agents are not complexed with said sulfoalkyl ether cyclodextrin.

摘要翻译： 一种多层组合的快速和控释固体药物制剂，其包含：至少一个受控释放的第一层，其包含第一治疗剂，释放速率调节剂和磺基烷基醚环糊精的物理混合物，用于以受控的速率释放所述第一治疗剂 进入第一个使用环境; 以及至少一个包含第二治疗剂和磺基烷基醚环糊精的物理混合物的快速释放第二层，用于将所述第二治疗剂快速释放到第二使用环境中; 其中，所述第一和第二层并列; 并且所述第一和第二治疗剂各自的主要部分与所述磺基烷基醚环糊精不复合。