公开(公告)号：EP1553931A1

公开(公告)日：2005-07-20

申请号：EP03753011.0

申请日：2003-05-08

申请人： Cytokinetics, Inc. ,  SMITHKLINE BEECHAM CORPORATION

发明人： FENG, Bainian ,  BERGNES, Gustave ,  MORGANS, David, J., C., Jr. ,  DHANAK, DashyantGlaxoSmithKline ,  KNIGHT, Steven, DavidGlaxoSmithKline ,  DARCY, Michael, GerardGlaxoSmithKline

IPC分类号： A61K31/00 ,  C07D413/00

CPC分类号： C07D403/06

摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

公开(公告)号：EP1503986A2

公开(公告)日：2005-02-09

申请号：EP02806491.3

申请日：2002-12-20

申请人： Cytokinetics, Inc.

发明人： MALIK, Fady ,  TOMASI, Adam, Lewis ,  FENG, Bainian ,  KRAYNACK, Erica, Anne ,  ELIAS, Kathleen ,  LU, Pu-Ping ,  SMITH, Whitney, Walter ,  QIAN, Xiangping ,  MORGANS, David, J., Jr.

IPC分类号： C07D213/02 ,  C07D261/06 ,  A61K31/44 ,  A61K31/42

CPC分类号： C07D401/12 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/513 ,  C07D213/65 ,  C07D261/18 ,  C07D333/38 ,  C07D409/12 ,  C07D413/12

摘要： Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

公开(公告)号：EP1226129A1

公开(公告)日：2002-07-31

申请号：EP00976656.9

申请日：2000-10-26

申请人： Cytokinetics, Inc.

发明人： FINER, Jeffrey, T. ,  BERGNES, Gustave ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C.

IPC分类号： C07D239/91 ,  A61K31/517 ,  A61P37/02

CPC分类号： C07D239/91

摘要： Quinazolinones of formulae (1a), (1b), (1c) and (1d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.

公开(公告)号：EP1503986B1

公开(公告)日：2015-09-30

申请号：EP02806491.3

申请日：2002-12-20

申请人： Cytokinetics, Inc.

发明人： MALIK, Fady ,  TOMASI, Adam, Lewis ,  FENG, Bainian ,  KRAYNACK, Erica, Anne ,  ELIAS, Kathleen ,  LU, Pu-Ping ,  SMITH, Whitney, Walter ,  QIAN, Xiangping ,  MORGANS, David, J., Jr.

IPC分类号： C07D213/02 ,  C07D261/06 ,  A61K31/44 ,  A61K31/42

CPC分类号： C07D401/12 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/513 ,  C07D213/65 ,  C07D261/18 ,  C07D333/38 ,  C07D409/12 ,  C07D413/12

公开(公告)号：EP1226129B1

公开(公告)日：2006-05-24

申请号：EP00976656.9

申请日：2000-10-26

申请人： Cytokinetics, Inc.

发明人： FINER, Jeffrey, T. ,  BERGNES, Gustave ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C.

IPC分类号： C07D239/91 ,  A61K31/517 ,  A61P37/02

CPC分类号： C07D239/91

摘要： Quinazolinones of formulae (1a), (1b), (1c) and (1d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.

公开(公告)号：EP1296959B1

公开(公告)日：2006-04-19

申请号：EP01932769.1

申请日：2001-04-27

申请人： Cytokinetics, Inc.

发明人： FINER, Jeffrey, T. ,  BERGNES, Gustav ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C. ,  MORGANS, David, J., Jr.

IPC分类号： C07D239/91 ,  A61K31/517 ,  A61P37/02 ,  C07D239/90 ,  A61P35/00

CPC分类号： C07D239/90 ,  C07D239/91

摘要： Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.

公开(公告)号：EP1296959A1

公开(公告)日：2003-04-02

申请号：EP01932769.1

申请日：2001-04-27

申请人： Cytokinetics, Inc.

发明人： FINER, Jeffrey, T. ,  BERGNES, Gustav ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C. ,  MORGANS, David, J., Jr.

IPC分类号： C07D239/91 ,  A61K31/517 ,  A61P37/02 ,  C07D239/90 ,  A61P35/00

CPC分类号： C07D239/90 ,  C07D239/91

摘要： Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.