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    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    3.
    发明公开
    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS 审中-公开
    某些化学物质，组成和方法

    公开(公告)号：EP1959947A2

    公开(公告)日：2008-08-27

    申请号：EP06845482.6

    申请日：2006-12-13

    申请人： Cytokinetics, Inc.

    发明人： MORGAN, Bradley P. ,  MALIK, Fady ,  MORGANS, David J. Jr.

    IPC分类号： A61K31/195

    CPC分类号： A61K31/195 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

    摘要： Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.

    METHODS FOR IMPROVING DIAPHRAGM FUNCTION
    4.
    发明公开
    METHODS FOR IMPROVING DIAPHRAGM FUNCTION 审中-公开
    提高隔膜功能的方法

    公开(公告)号：EP2834269A1

    公开(公告)日：2015-02-11

    申请号：EP13773086.7

    申请日：2013-04-01

    申请人： Cytokinetics, Inc. ,  Jasper, Jeffrey R. ,  Malik, Fady ,  Hwee, Darren T.

    发明人： JASPER, Jeffrey R. ,  MALIK, Fady ,  HWEE, Darren T.

    IPC分类号： C07K14/47

    CPC分类号： A61K31/52 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  Y02A50/465 ,  Y02A50/469

    摘要： Provided are compositions and methods for improving diaphragm function in a patient. In some embodiments, the methods comprise administering to a patient or contacting a diaphragm skeletal muscle fiber with an effective amount of a skeletal muscle troponin activator or pharmaceutically acceptable salt thereof. Likewise, compositions and methods are also provided for increasing the function, activity, efficiency, sensitivity to calcium, or time to fatigue of skeletal muscle in the diaphragm. In some embodiments, the patient receiving such administration suffers from diaphragmatic atrophy.

    摘要翻译： 提供了改善患者膈肌功能的组合物和方法。 在一些实施方案中，所述方法包括给予患者或使隔膜骨骼肌纤维接触有效量的骨骼肌肌钙蛋白活化剂或其药学上可接受的盐。 同样地，还提供了用于增加膈肌中的功能，活性，效率，对钙的敏感性或骨骼肌疲劳时间的组合物和方法。 在一些实施方案中，接受这种施用的患者患有膈肌萎缩。

    METHODS OF REDUCING DECLINE IN VITAL CAPACITY
    7.
    发明公开
    METHODS OF REDUCING DECLINE IN VITAL CAPACITY 审中-公开
    VERFAHREN ZUR REDUZIERUNG DESRÜCKGANGSDERVITALKAPAZITÄT

    公开(公告)号：EP3137622A1

    公开(公告)日：2017-03-08

    申请号：EP15785560.2

    申请日：2015-04-28

    申请人： Cytokinetics, Inc.

    发明人： SHEFNER, Jeremy, M. ,  WOLFF, Andrew, A. ,  MALIK, Fady ,  ANDREWS, Jinsy, A.

    IPC分类号： C12Q1/00

    CPC分类号： A61K31/4985 ,  A61K31/00 ,  A61K31/428 ,  A61K45/06 ,  A61K2300/00

    摘要： Provided herein are compositions and methods for reducing the decline in vital capacity in a subject by administering to the subject a skeletal muscle troponin activator. Also provided are compositions and methods for reducing respiratory decline in a subject, as measured by slow vital capacity (SVC), by administering to the subject a skeletal muscle troponin activator.

    摘要翻译： 本文提供了通过向受试者施用骨骼肌肌钙蛋白激活剂来减少受试者的活力下降的组合物和方法。 还提供了通过对受试者施用骨骼肌肌钙蛋白激活剂，通过缓慢的肺活量（SVC）测量来减少受试者的呼吸衰竭的组合物和方法。