公开(公告)号：EP0893125A1

公开(公告)日：1999-01-27

申请号：EP97904584.6

申请日：1997-02-20

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： AKASHI, Mitsuru ,  KISHIDA, Akio ,  SAKUMA, Shinji, Daiichi Pharmaceutical Co., Ltd. ,  KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd.

IPC分类号： A61K47/30

CPC分类号： A61K47/32 ,  A61K9/1635

摘要： The present invention is directed to particulate carriers useful as drug carriers in a drug delivery system (DDS) and to pharmaceutical compositions making use of such carriers. The invention is characterized by the use, as the particulate carrier, of: graft copolymer (A) whose graft chain is poly N-alkylacrylamide chain, poly N-alkylmethacrylamide chain, etc.; and a composition containing a combination of the graft copolymer (A) and at least one graft copolymer selected from the group consisting of graft copolymers (B-1) having polyacrylic acid or polymethacrylic acid as the graft chain and graft copolymers (B-2) having a polyvinyl amine compound as the graft chain.

摘要翻译： 本发明涉及用作药物递送系统（DDS）中的药物载体的颗粒载体和利用这种载体的药物组合物。 本发明的特征在于使用接枝共聚物（A）作为颗粒载体，其接枝链是聚N-烷基丙烯酰胺链，聚N-烷基甲基丙烯酰胺链等; 和含有接枝共聚物（A）和至少一种选自具有聚丙烯酸或聚甲基丙烯酸作为接枝链的接枝共聚物（B-1）和接枝共聚物（B-2）的组合的组合物， 具有聚乙烯胺化合物作为接枝链。