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公开(公告)号：EP1121936A4
公开(公告)日：2004-11-17
申请号：EP99943391
申请日：1999-09-17
申请人： DAIICHI SEIYAKU CO
CPC分类号： A61K38/22 , Y10S514/909
摘要： Novel preventives and/or remedies for obesity. These preventives and/or remedies contain as the active ingredient stanniocalcin. Because of having an excellent activity of inhibiting the differentiation and maturation of adipocytes, they are useful as drugs for preventing and/or treating obesity.
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公开(公告)号：EP1070758A4
公开(公告)日：2005-01-12
申请号：EP99913613
申请日：1999-04-09
申请人： DAIICHI SEIYAKU CO
发明人： GOTO MASAAKI , TOMOYASU AKIHIRO , YANO KAZUKI , KOBAYASHI FUMIE , NAKAGAWA NOBUAKI , YASUDA HISATAKA , YAMAGUCHI KYOJI , KINOSAKI MASAHIKO , MOCHIZUKI SHIN-ICHI , NAKAKARUMAI TADASHI , MORINAGA TOMONORI , TSUDA EISUKE , HIGASHIO KANJI
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K1/16 , C07K1/20 , C07K1/22 , C12N11/14 , C12P21/02 , C12R1/91
摘要： A novel protein which is a glycoprotein having activities of suppressing the differentiation and/or maturation of adipocytes, having a molecular weight of about 45 kDa under nonreducing conditions and about 28 kDa and/or about 23 kDa under reducing conditions, and having an affinity for heparin. A process for producing the above protein which comprises culturing human fibroblasts and purifying the product from the liquid culture medium by ion exchange column, affinity column and reversed phase column chromatographs. A cDNA encoding the above protein and a process for producing the above protein by using this cDNA. This protein is useful in medicinal compositions aiming at preventing and/or treating obesity, as an antigen for establishing immunological diagnosis, etc.
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