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公开(公告)号：EP1415992A4
公开(公告)日：2006-07-26
申请号：EP02762760
申请日：2002-08-08
申请人： DAIICHI SEIYAKU CO
发明人： OHTA TOSHIHARU , KOMORIYA SATOSHI , YOSHINO TOSHIHARU , UOTO KOUICHI , NAKAMOTO YUMI , NAITO HIROYUKI , MOCHIZUKI AKIYOSHI , NAGATA TSUTOMU , KANNO HIDEYUKI , HAGINOYA NORIYASU , YOSHIKAWA KENJI , NAGAMOCHI MASATOSHI , KOBAYASHI SYOZO , ONO MAKOTO
IPC分类号： C07D401/12 , A61K20060101 , A61K31/428 , A61K31/429 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61P20060101 , A61P7/02 , A61P9/00 , C07D20060101 , C07D209/42 , C07D401/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14 , C07D519/00 , C07K5/06 , C07K5/08
CPC分类号： C07D209/42 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04 , C07K5/06191 , C07K5/0827
摘要： Compounds represented by the following general formula (1), salts thereof, solvates of the same or N-oxides of the same: Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent each hydrogen, etc.; Q1 represents optionally substituted, saturated or unsaturated 5- or 6-membered hydrocarbyl, etc.; Q2 represents a single bond, etc.; Q3 represents the following group; (wherein Q5 represents C1-8 alkylene, etc.); and T0 and T1 represent each carbonyl, etc. These compounds are useful as preventives and/or remedies for brain infarction, cerebral embolism, myocardial infarction, angina, pulmonary infarction, pulmonary embolism, Buerger’s disease, bottom venous thrombosis, disseminated intravascular coagulation, thrombosis following artificial valve/joint replacement, thrombosis and reocclusion following circulation reconstruction, systemic inflammatory responsive syndrome (SIRS), multiple organ dysfunction (MODS), thrombosis in extracorporeal circulation or blood coagulation in collecting blood.
摘要翻译： （1）表示的化合物，其盐，相同的溶剂化物或相同的N-氧化物：Q1-Q2-T0-N（R1）-Q3-N（R2）-T1-Q4（1） 其中R1和R2代表每个氢等; Q1表示任选取代的饱和或不饱和的5或6元烃基等; Q2代表单键等; Q3代表以下组别; （其中Q5表示C1-8亚烷基等）; 这些化合物可用作脑梗塞，脑栓塞，心肌梗塞，心绞痛，肺梗塞，肺栓塞，伯格氏病，下肢静脉血栓形成，弥散性血管内凝血，血栓形成等的预防剂和/或治疗剂 继循环重建，全身炎症反应综合征（SIRS），多器官功能障碍（MODS），体外循环中的血栓形成或血液凝固后的人工瓣膜/关节置换，血栓形成和再闭塞。
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公开(公告)号：EP1577301A4
公开(公告)日：2009-11-11
申请号：EP03768266
申请日：2003-12-25
申请人： DAIICHI SEIYAKU CO
发明人： OHTA TOSHIHARU , KOMORIYA SATOSHI , YOSHINO TOSHIHARU , UOTO KOUICHI , NAKAMOTO YUMI , NAITO HIROYUKI , MOCHIZUKI A , NAGATA TSUTOMU , KANNO HIDEYUKI , HAGINOYA NORIYASU , YOSHIKAWA KENJI , NAGAMOCHI M , KOBAYASHI SYOZO , ONO MAKOTO
IPC分类号： C07D513/04 , C07D213/75
CPC分类号： C07D498/04 , C07D213/75 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/14 , C07D519/00
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公开(公告)号：EP1405852A4
公开(公告)日：2006-07-26
申请号：EP02743653
申请日：2002-06-20
申请人： DAIICHI SEIYAKU CO
发明人： OHTA TOSHIHARU , KOMORIYA SATOSHI , YOSHINO TOSHIHARU , UOTO KOUICHI , NAKAMOTO YUMI , NAITO HIROYUKI , MOCHIZUKI AKIYOSHI , NAGATA TSUTOMU , KANNO HIDEYUKI , HAGINOYA NORIYASU , YOSHIKAWA KENJI , NAGAMOCHI MASATOSHI , KOBAYASHI SYOZO , ONO MAKOTO
IPC分类号： C07D401/12 , A61K20060101 , A61K31/428 , A61K31/429 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61P20060101 , A61P7/02 , A61P9/00 , A61P9/10 , A61P29/00 , C07D20060101 , C07D209/42 , C07D401/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14 , C07D519/00 , C07K5/06 , C07K5/08
CPC分类号： C07D401/12 , C07D209/42 , C07D401/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/14 , C07K5/06191 , C07K5/0827
摘要： Compounds represented by the following general formula (1), salts thereof, solvates of the same or N-oxides of the same: Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent each hydrogen, etc.; Q1 represents optionally substituted, saturated or unsaturated 5- or 6-membered hydrocarbyl, etc.; Q2 represents a single bond, etc.; Q3 represents the following group; (wherein Q5 represents C1-8 alkylene, etc.); and T0 and T1 represent each carbonyl, etc. These compounds are useful as preventives and/or remedies for brain infarction, cerebral embolism, myocardial infarction, angina, pulmonary infarction, pulmonary embolism, Buerger’s disease, bottom venous thrombosis, disseminated intravascular coagulation, thrombosis following artificial valve/joint replacement, thrombosis and reocclusion following circulation reconstruction, systemic inflammatory responsive syndrome (SIRS), multiple organ dysfunction (MODS), thrombosis in extracorporeal circulation or blood coagulation in collecting blood.
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公开(公告)号：EP1621537A4
公开(公告)日：2008-12-31
申请号：EP04728462
申请日：2004-04-20
申请人： DAIICHI SEIYAKU CO
发明人： OKAYAMA TORU , UOTO KOUICHI , ISHIYAMA TAKASHI , KANAYA NAOAKI , KIMURA YOUICHI , ISHIHARA HIROAKI , WATANABE TOSHIYUKI , FUJII KUNIHIKO
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/497 , A61K31/499 , A61K31/501 , A61K31/5377 , A61K31/553 , A61P7/02 , A61P9/10 , C07D401/06 , C07D413/06 , C07D413/14
CPC分类号： C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/497 , A61K31/499 , A61K31/501 , A61K31/5377 , A61K31/553
摘要： A compound represented by the general formula (I), a salt of the compound, or a solvate of either; a medicine containing any of these; an agent for the prevention of and/or treatments for ischemic diseases which contains any of these; and a platelet aggregation inhibitor containing any of these. The compound is useful as a potent platelet aggregation inhibitor which inhibits neither COX-1 nor COX-2.
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公开(公告)号：EP1221445A4
公开(公告)日：2003-05-28
申请号：EP00966445
申请日：2000-10-12
申请人： DAIICHI SEIYAKU CO
发明人： SOGA TSUNEHIKO , UOTO KOUICHI , TAKEDA YASUYUKI
IPC分类号： A61K31/337 , A61K31/4355 , A61P35/00 , C07D305/14 , C07D493/04
CPC分类号： C07D493/04 , A61K31/4355
摘要： Novel Taxol derivatives having various substituents as represented by general formula (I) and being usable as antitumor compounds which can be orally administered.
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