摘要:
1-[ω-(3,4-Dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives represented by general formula (I) and salts and N-oxide derivatives thereof, wherein R 1 and R 2 represent each hydrogen, halogeno, hydroxy, alkyl, alkoxy, hydroxymethyl, etc., or R 1 and R 2 form together methylenedioxy, trimethylene, etc.; R 3 represents hydrogen, etc.; R 4 represents hydrogen, hydroxy, alkyl, etc.; R 5 represents hydrogen, alkyl, etc.; p is an integer of from 2 to 6; and q is an integer of from 3 to 7; excluding the case where R 1 , R 2 , R 3 , R 4 and R 5 are all hydrogen, p is 2 and q is 5. The compounds have a potent effect of suppressing urinary reflex and thus are useful as a remedy for frequent urination and urinary incontinence.
摘要:
Acetamide derivatives represented by general formula (I) and physiologically acceptable acid-addition salts thereof, wherein X represents -O- or -NR 4 ; R 1 represents H, lower alkyl, lower alkenyl or cycloalkyl(lower)alkyl; R 2 represents lower alkyl, cycloalkyl, optionally substituted phenyl, etc.; R 3 represents H, lower alkyl or hydroxy(lower)alkyl; R 4 represents H, lower alkyl, etc.; R 5 represents H, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, etc.; R 6 represents H, lower alkyl, CF 3 or optionally substituted phenyl, or R 5 and R 6 together form -(CH 2 ) n -; R 7 represents H, halogeno, lower alkyl, lower alkoxy, CF 3 , OH, NH 2 , etc.; and R 8 represents H, halogeno, lower alkyl or lower alkoxy. The compounds act selectively on the peripheral BZ ω3 receptor and exhibit excellent pharmocological effects, which makes them useful as a remedy and preventive for central diseases, for example, diseases associated with anxiety, depression and epilepsy, etc.