专利检索 ap:("DANA-FARBER CANCER INSTITUTE, INC.") AND inv:"GRIFFIN, James, Douglas" 第 1 页

1.

发明公开
STAUROSPORINE DERIVATIVES AS INHIBITORS OF FLT3 RECEPTOR TYROSINE KINASE ACTIVITY 有权
标题翻译：星形孢菌素衍生物作为FLT3受体酪氨酸激酶影响的抑制剂

公开(公告)号：EP1441737A1

公开(公告)日：2004-08-04

申请号：EP02791654.3

申请日：2002-10-29

申请人： Novartis AG , Novartis Pharma GmbH , DANA-FARBER CANCER INSTITUTE, INC.

发明人： GRIFFIN, James, Douglas , MANLEY, Paul, William

IPC分类号： A61K31/535 , A61K31/55 , A61P35/02 , C07D498/22 , C07D487/04 , C07D487/14 , C07D519/00

CPC分类号： A61K31/407 , A61K31/535 , A61K31/55 , A61K31/553

摘要： The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic syndromes, and to a method of treating diseases involving deregulated FLT3 receptor tyrosine kinase activity.

2.

发明授权
STAUROSPORINE DERIVATIVES AS INHIBITORS OF FLT3 RECEPTOR TYROSINE KINASE ACTIVITY 有权
标题翻译：星形孢菌素衍生物作为FLT3受体酪氨酸激酶影响的抑制剂

公开(公告)号：EP1441737B1

公开(公告)日：2006-08-09

申请号：EP02791654.3

申请日：2002-10-29

申请人： Novartis AG , Novartis Pharma GmbH , DANA-FARBER CANCER INSTITUTE, INC.

发明人： GRIFFIN, James, Douglas , MANLEY, Paul, William

IPC分类号： A61K31/535 , A61K31/55 , A61P35/02 , C07D498/22 , C07D487/04 , C07D487/14 , C07D519/00

CPC分类号： A61K31/407 , A61K31/535 , A61K31/55 , A61K31/553

摘要： The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic syndromes, and to a method of treating diseases involving deregulated FLT3 receptor tyrosine kinase activity.

3.

发明公开
EPOTHILONE DERIVATIVES FOR THE TREATMENT OF MULTIPLE MYELOMA 审中-公开
标题翻译：埃博霉素衍生物对多发性骨髓瘤的治疗

公开(公告)号：EP1553939A1

公开(公告)日：2005-07-20

申请号：EP03807949.7

申请日：2003-10-10

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： LIN, Boris , ANDERSON, Kenneth, C. , GRIFFIN, James, Douglas

IPC分类号： A61K31/427 , A61P35/00

CPC分类号： A61K31/427 , A61K45/06 , A61K2300/00

摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having myeloma, especially myeloma which is resistant to conventional cytotoxic chemotherapy, comprising administering to said animal a therapeutically effective amount of an epothilone, especially an epothilone of formula (I), to a combination comprising an epothilone, for simultaneous, separate or sequential use; and to a pharmaceutical composition and a commercial package comprising said combination.