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1.发明公开SUSPENSION OF AN EPI-HNE PROTEIN, PROCESS OF PREPARATION THEREOF, DRY POWDER AEROSOL DERIVED THEREFROM, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID SUSPENSION OR AEROSOL, AND THEIR USES 有权暂停含EPI-HNE蛋白，制作方法，MADE干粉气雾剂药物组合物的制品含有该暂停或将该气溶胶和用途
公开(公告)号：EP1223972A1
公开(公告)日：2002-07-24
申请号：EP01992586.6
申请日：2001-10-26
申请人： DEBIOPHARM S.A.
发明人： PONCIN, Alain , SAUDUBRAY, François , BOKMAN, Anne
CPC分类号： A61K9/0078 , A61K38/57
摘要： The present invention concerns a suspension of crystallized particles of an EPI-hNE protein, methods for preparing said suspension, a dry powder aerosol derived from said suspension, an inhalable pharmaceutical formulation comprising said suspension or said dry powder aerosol, and the use of said inhalable pharmaceutical formulation in the treatment of various pathological conditions.
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公开(公告)号：EP1315757B1
公开(公告)日：2007-12-05
申请号：EP01967348.2
申请日：2001-08-30
申请人： DEBIOPHARM S.A.
发明人： PONCIN, Alain , SAUDUBRAY, Francois , BOKMAN, Anne
IPC分类号： C07K14/81
CPC分类号： C07K14/8114
摘要： The present invention concerns a process for the purification of EPI-HNE proteins, from the culture medium of a host strain for the expression of said proteins, comprising the steps of: (a) passing a derived part of the culture medium over an expanded bed of cationic exchange adsorbent or a mechanically and chemically inert micromembrane, in order to recover an eluate, (b) optionally conducting chromatographic separation of proteins, according to their hydrophobicity, on the resulting eluate, (c) passing the resulting eluate over a cationic exchange column, (d) optionally filtering the resulting medium such as to obtain a sterile filtrate, and optionally further comprising the step of (e) causing precipitation of EPI-HNE in a crystallised form and recovering the protein crystals.
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3.发明授权SUSPENSION OF AN EPI-HNE PROTEIN, PROCESS OF PREPARATION THEREOF, DRY POWDER AEROSOL DERIVED THEREFROM, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID SUSPENSION OR AEROSOL, AND THEIR USES 有权暂停含EPI-HNE蛋白，制作方法，MADE干粉气雾剂药物组合物的制品含有该暂停或将该气溶胶和用途
公开(公告)号：EP1223972B1
公开(公告)日：2003-07-23
申请号：EP01992586.6
申请日：2001-10-26
申请人： DEBIOPHARM S.A.
发明人： PONCIN, Alain , SAUDUBRAY, François , BOKMAN, Anne
CPC分类号： A61K9/0078 , A61K38/57
摘要： The present invention concerns a suspension of crystallized particles of an EPI-hNE protein, methods for preparing said suspension, a dry powder aerosol derived from said suspension, an inhalable pharmaceutical formulation comprising said suspension or said dry powder aerosol, and the use of said inhalable pharmaceutical formulation in the treatment of various pathological conditions.
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公开(公告)号：EP1315757A2
公开(公告)日：2003-06-04
申请号：EP01967348.2
申请日：2001-08-30
申请人： DEBIOPHARM S.A.
发明人： PONCIN, Alain , SAUDUBRAY, Francois , BOKMAN, Anne
IPC分类号： C07K14/81
CPC分类号： C07K14/8114
摘要： The present invention concerns a process for the purification of EPI-HNE proteins, from the culture medium of a host strain for the expression of said proteins, comprising the steps of: (a) passing a derived part of the culture medium over an expanded bed of cationic exchange adsorbent or a mechanically and chemically inert micromembrane, in order to recover an eluate, (b) optionally conducting chromatographic separation of proteins, according to their hydrophobicity, on the resulting eluate, (c) passing the resulting eluate over a cationic exchange column, (d) optionally filtering the resulting medium such as to obtain a sterile filtrate, and optionally further comprising the step of (e) causing precipitation of EPI-HNE in a crystallised form and recovering the protein crystals.
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