公开(公告)号：EP1311269A4

公开(公告)日：2006-05-17

申请号：EP01957581

申请日：2001-08-02

申请人： DMI BIOSCIENCES INC

发明人： BAR-OR DAVID ,  CURTIS C GERALD ,  RAO NAGARAJA K R ,  THOMAS GREG

IPC分类号： A61K31/495 ,  A61K31/496 ,  A61P7/02 ,  A61P11/00 ,  A61P11/06 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/08 ,  A61P43/00 ,  C07D241/04

CPC分类号： A61K31/495 ,  A61K9/0014 ,  A61K9/0073 ,  A61K31/496

摘要： The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.

公开(公告)号：EP1220870A4

公开(公告)日：2004-04-07

申请号：EP00967163

申请日：2000-09-29

申请人： DMI BIOSCIENCES INC

发明人： BAR-OR DAVID ,  CURTIS C GERALD ,  LAU EDWARD ,  RAO NAGARAJA K R ,  WINKLER JAMES V ,  CROOK WANNELL M

IPC分类号： A61K38/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/28 ,  C07K5/113 ,  C07K7/00 ,  C07K14/76 ,  C07K14/795 ,  C07K5/10

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/76 ,  C07K14/795