公开(公告)号：EP3283056A1

公开(公告)日：2018-02-21

申请号：EP16780996.1

申请日：2016-04-18

申请人： The Research Foundation For The State University Of New York University at Buffalo

发明人： LOVELL, Jonathan ,  SHAO, Shuai ,  GENG, Jumin ,  HUANG, Wei-Chiao ,  LEE, Shwu-Maan ,  KING, Charles, Richter

IPC分类号： A61K9/127 ,  A61K31/409 ,  A61K38/41 ,  A61K47/48 ,  C07F15/06 ,  C07K14/795

CPC分类号： A61K47/6911 ,  A61K9/127 ,  A61K38/162 ,  A61K38/41 ,  A61K47/544 ,  B82Y5/00 ,  C07K14/795 ,  C07K2319/21

摘要： The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

公开(公告)号：EP2968478A1

公开(公告)日：2016-01-20

申请号：EP14769521.7

申请日：2014-03-11

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： GLADWIN, Mark, T. ,  TEJERO BRAVO, Jesus

IPC分类号： A61K38/41 ,  A61P39/02 ,  C07K14/795

CPC分类号： C07K14/795 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/41

摘要： Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.

摘要翻译： 本文描述了一种新的解毒剂，用于从血红蛋白中快速消除一氧化碳，包括脑，心脏和红细胞血红蛋白。 所公开的疗法包括使用修饰的人球蛋白，特别是在残基64修饰的神经球蛋白和在残基81修饰的细胞因子，其以极高的亲和力结合一氧化碳。 单体突变体球蛋白注入血液中，迅速不可逆地螯合一氧化碳，从而限制一氧化碳对细胞呼吸和氧气转运和利用的毒性作用。

公开(公告)号：EP2476701B8

公开(公告)日：2014-09-24

申请号：EP10815682.9

申请日：2010-09-08

申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"

发明人： NEBOLSIN, Vladimir Evgenievich ,  ZHELTUKHINA, Galina Alexandrovna

IPC分类号： C07K14/805 ,  C07D487/22 ,  C07F15/02 ,  A61K38/42 ,  A61P31/04 ,  A61P31/10

CPC分类号： C07D487/22 ,  A61K31/555 ,  A61K38/00 ,  C07F15/025 ,  C07K14/795 ,  C07K14/805

公开(公告)号：EP1038004A1

公开(公告)日：2000-09-27

申请号：EP98962953.0

申请日：1998-12-08

申请人： NOVO NORDISK BIOTECH, INC.

发明人： ELROD, Susan, L.

IPC分类号： C12N15/53 ,  C07K14/795 ,  C12N1/15

CPC分类号： C12N9/001 ,  C07K14/795 ,  C12N9/0083

摘要： The present invention relates to methods for producing hemoproteins comprising: a) cultivating a mutant of a parent fungal cell in a nutrient medium suitable for production of the hemoprotein, wherein (i) the mutant comprises one or more first nucleic acid sequences comprising a modification of one or more genes encoding one or more heme catabolic enzymes or a control sequence thereof and (ii) the mutant produces less of the one or more heme catabolic enzymes and more of the hemoprotein than the parent cell when cultivated under the same conditions; and b) recovering the hemoprotein from the nutrient medium of the mutant cell.

公开(公告)号：EP0775157A4

公开(公告)日：1997-09-24

申请号：EP95926627

申请日：1995-07-07

申请人： UNIV DUKE

发明人： BONAVENTURA JOSEPH

IPC分类号： C07D487/22 ,  A61K31/40 ,  A61K38/00 ,  A61P7/08 ,  C07K1/02 ,  C07K14/765 ,  C07K14/795 ,  C07K1/32

CPC分类号： C07K14/795 ,  A61K38/00 ,  C07K14/765 ,  Y10S530/83

摘要： The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.

公开(公告)号：EP0584552A3

公开(公告)日：1994-08-17

申请号：EP93111942.4

申请日：1993-07-26

申请人： YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

发明人： Scherz, Avigdor ,  Salomon, Yoram ,  Fiedor, Leszek

IPC分类号： A61K47/48 ,  A61K31/40 ,  A61K37/02 ,  A61K39/44

CPC分类号： A61K49/0036 ,  A61K41/0071 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6851 ,  A61K49/00 ,  A61K49/0052 ,  A61K49/0056 ,  C07K14/685 ,  C07K14/795 ,  C12N9/18 ,  C12P17/182

摘要： Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain.The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.

摘要翻译： 本发明提供了具有氨基酸，肽和蛋白质的叶绿素（Chl）和细菌叶绿素（Bchl）衍生物的缀合物。氨基酸，肽或蛋白质残基直接连接到Chl或Bchl残基的17-丙酸基团 通过链。缀合物用作光动力学治疗和肿瘤诊断中的光敏剂。 细胞特异性配体如激素，生长因子或肿瘤特异性抗体的缀合将靶向肿瘤部位的Chl或Bchl部分。 因此，与黑素细胞刺激激素的缀合物适用于黑素瘤肿瘤的光动力学治疗。

公开(公告)号：EP2968478A4

公开(公告)日：2016-09-07

申请号：EP14769521

申请日：2014-03-11

申请人： UNIV PITTSBURGH

发明人： GLADWIN MARK T ,  TEJERO BRAVO JESUS

IPC分类号： A61K38/41 ,  A61P39/02 ,  C07K14/795

CPC分类号： C07K14/795 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/41

摘要： Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.

摘要翻译： 本文描述了一种用于从血红蛋白（包括脑，心脏和红细胞血红蛋白）快速消除一氧化碳的新的解毒剂。 所公开的治疗涉及使用修饰的人球蛋白，特别是在残基64处修饰的神经球蛋白和在残基81修饰的细胞球蛋白，其以非常高的亲和力结合一氧化碳。 单体突变体珠蛋白注入血液，其中它们迅速和不可逆地螯合一氧化碳，从而限制一氧化碳对细胞呼吸和氧气运输和利用的毒性作用。

公开(公告)号：EP2476701A1

公开(公告)日：2012-07-18

申请号：EP10815682.9

申请日：2010-09-08

申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"

发明人： NEBOLSIN, Vladimir Evgenievich ,  ZHELTUKHINA, Galina Alexandrovna

IPC分类号： C07K14/805 ,  C07D487/22 ,  C07F15/02 ,  A61K38/42 ,  A61P31/04 ,  A61P31/10

CPC分类号： C07D487/22 ,  A61K31/555 ,  A61K38/00 ,  C07F15/025 ,  C07K14/795 ,  C07K14/805

摘要： The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel hemin derivatives. The advantages of antibacterial agents based on hemin derivatives are their biocompatibility, biodegradability, high effectiveness against resistant bacteria and widespread microfungi that are harmful to humans, and freedom from toxicity and side effects.

摘要翻译： 本发明涉及新型抗菌剂，包括抗菌和抗真菌剂，基于通式（I）的血红素衍生物的试剂和组合物，以及新型海明明衍生物的生产。 基于血红素衍生物的抗菌剂的优点是其对人体有害的抗菌细菌和广泛的微生物的生物相容性，生物降解性，高效性，无毒副作用。

公开(公告)号：EP0775157B1

公开(公告)日：2001-10-31

申请号：EP95926627.1

申请日：1995-07-07

申请人： DUKE UNIVERSITY

发明人： BONAVENTURA, Joseph

IPC分类号： C07K1/32 ,  C07K14/765

CPC分类号： C07K14/795 ,  A61K38/00 ,  C07K14/765 ,  Y02A50/411 ,  Y10S530/83

摘要： The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.

公开(公告)号：EP0168832B1

公开(公告)日：1993-09-15

申请号：EP85108987.0

申请日：1985-07-18

申请人： Nippon Petrochemicals Co., Ltd.

发明人： Bommer, Jerry C. ,  Burnham, Bruce F.

IPC分类号： C07D487/22 ,  C07D207/44 ,  A61K31/40 ,  C07K5/06 ,  A61K37/02

CPC分类号： C07D207/44 ,  A61K38/00 ,  A61K41/0071 ,  A61K49/0036 ,  A61K49/0052 ,  C07K5/06104 ,  C07K5/06113 ,  C07K5/0819 ,  C07K5/1021 ,  C07K14/795