公开(公告)号：EP2154243A4

公开(公告)日：2011-07-06

申请号：EP08752599

申请日：2008-05-12

申请人： DNAVEC CORP ,  UEDA YASUJI

发明人： INOUE MAKOTO ,  HASEGAWA MAMORU ,  YONEMITSU YOSHIKAZU ,  HARADA YUI

IPC分类号： C12N5/0784 ,  C12N5/06

CPC分类号： C12N5/0639 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26

公开(公告)号：EP2048232A4

公开(公告)日：2010-10-13

申请号：EP07768079

申请日：2007-07-03

申请人： DNAVEC CORP

发明人： YOU JUN ,  INOUE MAKOTO ,  HASEGAWA MAMORU

IPC分类号： C12N15/09 ,  A61K48/00 ,  C12N5/10 ,  C12N7/00

CPC分类号： C12N15/86 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2820/00

公开(公告)号：EP2631290A4

公开(公告)日：2015-06-10

申请号：EP11834485

申请日：2011-10-21

申请人： UNIV HOKKAIDO NAT UNIV CORP ,  UNIV SAPPORO MEDICAL ,  DNAVEC CORP

发明人： SHIDA HISATOSHI ,  SOBUE TOMOYOSHI ,  KATO KAZUNORI ,  INOUE MAKOTO ,  HASEGAWA MAMORU

IPC分类号： C12N15/09

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/545 ,  C12N15/86 ,  C12N2710/24143 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2760/18843

摘要： To provide a set of virus vectors which can be used for producing a prime/boost vaccine that can activate both cellular immunity and humoral immunity and is effective on infections by pathogenic microorganisms and malignant tumors which are generally believed to be difficult to be treated by vaccine therapy. [Solution] Provided is a set of virus vectors for prime/boost vaccines, comprising the following virus vector (a) and virus vector (b): (a) a vaccinia virus vector which carries a gene encoding an immunogenic polypeptide in such a manner that the gene can be expressed; and (b) a Sendal virus vector which carries the gene encoding the immunogenic polypeptide in such a manner that the gene can be expressed.

公开(公告)号：EP1983048A4

公开(公告)日：2009-04-22

申请号：EP07706883

申请日：2007-01-17

申请人： DNAVEC CORP

发明人： YOU JUN ,  TABATA TOSHIAKI ,  INOUE MAKOTO ,  SHU TSUGUMINE ,  HASEGAWA MAMORU

IPC分类号： C12N15/09 ,  C12N7/00 ,  C12P21/02

CPC分类号： C12N15/86 ,  C12N7/00 ,  C12N2760/18823 ,  C12N2760/18843 ,  C12P21/02

摘要： By devising an expression system for protein with the coexistence of MiniSeV-SeV particles, studies are made on the ability of this expressions system to transfer a target gene into a target cell and the ability to express the target gene in the target cell. As a result, it is clarified that the expression system as described above sustains a high ability to transfer a target gene into a target cell and a high ability to express the target gene in the target cell.

公开(公告)号：EP2363472A4

公开(公告)日：2012-08-01

申请号：EP09823696

申请日：2009-10-30

申请人： DNAVEC CORP

发明人： INOUE MAKOTO ,  SAEKI KOICHI ,  YOU JUN ,  TABATA TOSHIAKI ,  IWASAKI HITOSHI ,  SHU TSUGUMINE ,  HASEGAWA MAMORU

IPC分类号： C12N15/09 ,  A61K35/76 ,  A61K48/00 ,  A61P43/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/62 ,  C12N15/67 ,  C12P21/02

CPC分类号： C12N15/67 ,  A61K2039/53 ,  C07K2319/55 ,  C12N15/86 ,  C12N2760/18843

摘要： The present invention provides methods for enhancing protein expression from an RNA viral vector and RNA viral vectors with enhanced protein expression capacity. The present inventors successfully increased the level of protein expression significantly by expressing the proteins fused with an AB5B protein from RNA viral vectors. Effective gene therapy, gene vaccination, monoclonal antibody preparation, or such can be achieved by using a gene transfer RNA viral vector of the present invention.