专利检索 ap:("DUKE UNIVERSITY") AND inv:"SEMPOWSKI, Gregory, D." 第 1 页

1.

发明公开
SUBSTANTIALLY NON-TOXIC BIOLOGICALLY ACTIVE MUCOSAL ADJUVANTS IN VERTEBRATE SUBJECTS 审中-公开
标题翻译：在脊椎动物中基本上是无毒的生物活性粘膜

公开(公告)号：EP1121147A1

公开(公告)日：2001-08-08

申请号：EP99951772.5

申请日：1999-10-06

申请人： DUKE UNIVERSITY

发明人： STAATS, Herman, F. , HAYNES, Barton, F. , PATEL, Dhavalkumar, D. , SEMPOWSKI, Gregory, D.

IPC分类号： A61K39/00 , A61K47/00 , C07K14/52 , C07K14/54 , C07K14/545

CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55538 , Y10S514/885

摘要： A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1α (IL-1α) and interleukin-1β (IL-1β).