公开(公告)号：EP2946206A4

公开(公告)日：2016-08-31

申请号：EP14740167

申请日：2014-01-17

申请人： DYAX CORP

发明人： JOSEPH KUSUMAM ,  KAPLAN ALLEN P

IPC分类号： G01N33/48 ,  C12Q1/56 ,  G01N33/50

CPC分类号： G01N33/573 ,  C07K14/435 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/76 ,  C12Q1/37 ,  G01N33/6893 ,  G01N2333/4706 ,  G01N2333/8121 ,  G01N2333/96455 ,  G01N2333/96458 ,  G01N2800/32 ,  G01N2800/52 ,  G01N2800/70

摘要： The invention provides assay methods of detecting plasma protease CI inhibitor (C1-INH) that binds plasma kallikrein, Factor XII, or both, and uses thereof for identifying subjects at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment.