公开(公告)号：EP4163300A1

公开(公告)日：2023-04-12

申请号：EP21817796.2

申请日：2021-06-02

申请人： Daegu Gyeongbuk Institute Of Science and Technology

发明人： YEA, Kyung Moo ,  LEE, Beom Yong ,  JEONG, Jong Won

IPC分类号： C07K16/28 ,  A61P3/04 ,  A61P35/00 ,  A23L33/17 ,  A61K39/00

摘要： The present invention relates to a GFRAL-antagonistic antibody and a use thereof, and more particularly, to an anti-GFRAL antibody comprising a heavy chain CDR and a light chain CDR of specific sequences, and an antigen-binding fragment thereof. The anti-GFRAL antibody is expected to be usefully utilized for ameliorating or treating anorexia-cachexia syndrome associated with cancer, and adverse effects of chemotherapeutic drugs.

公开(公告)号：EP4406972A1

公开(公告)日：2024-07-31

申请号：EP22873130.3

申请日：2022-09-05

申请人： Daegu Gyeongbuk Institute Of Science and Technology

发明人： YEA, Kyung Moo ,  LEE, Beom Yong ,  JEONG, Jong Won

IPC分类号： C07K16/28 ,  A61P1/14 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K39/00 ,  A61P1/14

摘要： The present invention relates to a GFRAL-antagonistic antibody having improved affinity and a use thereof, and more particularly, the present invention relates to an anti-GFRAL antibody having improved affinity, comprising a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. The anti-GFRAL antibody having improved affinity exhibits higher binding ability to a GFRAL protein than a conventional anti-GFRAL antibody, and thus is expected to be effectively used for improving or treating cancer-related anorexia or cachexia syndrome and side effects of chemotherapy anticancer drugs.