公开(公告)号：EP4105217A1

公开(公告)日：2022-12-21

申请号：EP21761078.1

申请日：2021-02-26

申请人： Daegu-Gyeongbuk Medical Innovation Foundation ,  Immunoforge Co., Ltd.

发明人： LEE, Doohyun ,  LEE, Seungyeon ,  HAN, Ye Ri ,  IM, Chun Young ,  KIM, So Young ,  KIM, Nam Hui ,  CHOI, Hwan Geun ,  KO, Eunhwa ,  MOON, Heegyum ,  LEE, Sun Joo ,  KIM, Sang Bum ,  KIM, Hyo-Ji ,  LEE, Sion ,  AHN, Sung-Min ,  CHANG, Kiho ,  LEE, Eunkyu ,  KWON, Hyun Jin ,  JEONG, Myeong-Sook ,  KIM, Ji Young

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/496 ,  A61P35/00 ,  A23L33/10

摘要： The present invention relates to a 3-((8-((1H-pyrazol-4-yl)amino)imidazo[1,2-a]pyridin-3-yl)ethynyl)-N-phenylbenzamide derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. The derivative can significantly inhibit the proliferation of cancer cells by inhibiting kinases, particularly Bcr-Abl kinase or Bcr-Abl (T315I) kinase. Therefore, the derivative can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer.

公开(公告)号：EP4159718A1

公开(公告)日：2023-04-05

申请号：EP21814082.0

申请日：2021-04-05

申请人： Daegu-Gyeongbuk Medical Innovation Foundation ,  Trineuro

发明人： SONG, Minsoo ,  IM, Chun Young ,  PARK, Ga Young ,  KO, Eun Bi ,  KANG, Jihee ,  BAE, Seri ,  KIM, Soong-Hyun ,  PARK, Yoojin ,  LEE, Eunhye ,  CHOI, Yujeong ,  JOO, Jeongmin ,  LEE, Sion ,  SHIN, Chan Young ,  KWON, Kyoung Ja ,  HWANG, Hee Jong ,  PAUDEL, Suresh ,  JEON, Se Jin ,  CHO, Kyu Suk

IPC分类号： C07D211/34 ,  A61K31/445 ,  A61K31/454 ,  A61P25/00 ,  A23L33/10 ,  A61P25/18 ,  C07D401/04

摘要： Disclosed are a sulfonamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.