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公开(公告)号：EP2938617B1
公开(公告)日：2017-08-09
申请号：EP13869782.6
申请日：2013-11-21
发明人： CHOI, Soo-Jin , LEE, Byung-Goo , YOON, Hee-Kyoon , PARK, Sung-Woo , JUN, Sun-Ah , LEE, Kyung-Ho , LIM, Byung-Jo
IPC分类号： C07D477/20
CPC分类号： C07D477/06 , C07D477/20 , C07D487/04
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公开(公告)号：EP2938617A1
公开(公告)日：2015-11-04
申请号：EP13869782.6
申请日：2013-11-21
发明人： CHOI, Soo-Jin , LEE, Byung-Goo , YOON, Hee-Kyoon , PARK, Sung-Woo , JUN, Sun-Ah , LEE, Kyung-Ho , LIM, Byung-Jo
IPC分类号： C07D487/04 , C07D403/12 , A61K31/407 , A61P31/00
CPC分类号： C07D477/06 , C07D477/20 , C07D487/04
摘要： The present invention provides a process for the preparation of meropenem trihydrate in high purity and high yield, through using a dry methanol solvate of meropenem. The process of the present invention can remarkably reduce the amount of residual solvents in the resulting product, thereby being able to obtain meropenem trihydrate in high purity.
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公开(公告)号：EP2370396B1
公开(公告)日：2019-02-20
申请号：EP09830523.8
申请日：2009-10-12
发明人： CHOI, Soo-Jin , LEE, Byung-Goo , LEE, Han-Kuk , LIM, Young-Mook , KIM, Wol-Young , LEE, Joon-Hwan
IPC分类号： C07C231/20 , C07C233/69 , A61K31/167 , C07C237/46
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4.发明公开
公开(公告)号：EP2370396A2
公开(公告)日：2011-10-05
申请号：EP09830523.8
申请日：2009-10-12
发明人： CHOI, Soo-Jin , LEE, Byung-Goo , LEE, Han-Kuk , LIM, Young-Mook , KIM, Wol-Young , LEE, Joon-Hwan
IPC分类号： C07C231/20 , C07C233/69 , A61K31/167
CPC分类号： C07C231/24 , C07C237/46
摘要： The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b) heating the resulting alcohol solution to obtain crystalline of Z isomer of iopromide; and a method for preparing a composition comprising the crystalline Z isomer of iopromide.
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