公开(公告)号：EP2625205A2

公开(公告)日：2013-08-14

申请号：EP11778519.6

申请日：2011-10-04

申请人： Daiichi Sankyo Company, Limited

发明人： WATANABE, Ichiro ,  HIRUMA, Yoshiharu ,  TSUDA, Eisuke ,  MATSUOKA, Tatsuji ,  OHTSUKA, Toshiaki ,  TAKAHASHI, Tohru ,  AGATSUMA, Toshinori ,  MILLER, Sandra ,  MÜHLBACHER, Robert ,  BAEHS, Kathrin-Ladetzki ,  RUNZ, Steffen ,  SCHUBERT, Ulrike ,  SCHUSTER, Ingrid ,  PONSEL, Dirk

IPC分类号： C07K16/28

CPC分类号： A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/92

摘要： An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.