公开(公告)号：EP2625205A2

公开(公告)日：2013-08-14

申请号：EP11778519.6

申请日：2011-10-04

申请人： Daiichi Sankyo Company, Limited

发明人： WATANABE, Ichiro ,  HIRUMA, Yoshiharu ,  TSUDA, Eisuke ,  MATSUOKA, Tatsuji ,  OHTSUKA, Toshiaki ,  TAKAHASHI, Tohru ,  AGATSUMA, Toshinori ,  MILLER, Sandra ,  MÜHLBACHER, Robert ,  BAEHS, Kathrin-Ladetzki ,  RUNZ, Steffen ,  SCHUBERT, Ulrike ,  SCHUSTER, Ingrid ,  PONSEL, Dirk

IPC分类号： C07K16/28

CPC分类号： A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/92

摘要： An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.

公开(公告)号：EP2396084B1

公开(公告)日：2016-05-11

申请号：EP10710107.3

申请日：2010-02-10

申请人： Daiichi Sankyo Company, Limited

发明人： KAWAIDA, Reimi ,  OHTSUKA, Toshiaki ,  AGATSUMA, Toshinori ,  RODLEY, Philip ,  MILLER, Sandra ,  SCHUBERT, Ulrike

IPC分类号： A61P35/00 ,  C07K16/28 ,  C12N15/86 ,  C12N5/10 ,  G01N33/53

CPC分类号： C07K16/2863 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  G01N2333/9121

公开(公告)号：EP2396084A1

公开(公告)日：2011-12-21

申请号：EP10710107.3

申请日：2010-02-10

申请人： Daiichi Sankyo Company, Limited

发明人： KAWAIDA, Reimi ,  OHTSUKA, Toshiaki ,  AGATSUMA, Toshinori ,  RODLEY, Philip ,  MILLER, Sandra ,  SCHUBERT, Ulrike

IPC分类号： A61P35/00 ,  A61K39/00 ,  C07K14/16 ,  C12N15/86 ,  G01N33/50 ,  C12N5/10 ,  C07K16/28

CPC分类号： C07K16/2863 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  G01N2333/9121

摘要： The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for MST1R, which plays an integral role in various disorders or conditions, such as cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the disclosure also can be used in the diagnostics field, as well as for further investigating the role of MST1R in the progression of disorders associated with tumors. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.