公开(公告)号：EP3356361A1

公开(公告)日：2018-08-08

申请号：EP16788802.3

申请日：2016-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： KHERA, Manoj Kumar ,  MATHUR, Tarun ,  SATTIGERI, Jitendra A. ,  MASUDA,, Nobuhisa ,  SONEDA, Tsuyoshi ,  KAGOSHIMA, Yoshiko ,  KONOSU, Toshiyuki ,  SUZUKI, Tetsuya ,  YAMAOKA, Makoto ,  ITOOKA, Ryo

IPC分类号： C07D417/14 ,  A61K31/433 ,  A61P31/00

摘要： Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use. Solution to the Problem. As a result of intensive research, the present inventors have found that a compound represented by general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof inhibits DNA gyrase GyrB subunit and/or topoisomerase IV ParE subunit, possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases.

公开(公告)号：EP3356361B1

公开(公告)日：2020-07-08

申请号：EP16788802.3

申请日：2016-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： KHERA, Manoj Kumar ,  MATHUR, Tarun ,  SATTIGERI, Jitendra A. ,  MASUDA,, Nobuhisa ,  SONEDA, Tsuyoshi ,  KAGOSHIMA, Yoshiko ,  KONOSU, Toshiyuki ,  SUZUKI, Tetsuya ,  YAMAOKA, Makoto ,  ITOOKA, Ryo

IPC分类号： C07D417/14 ,  A61K31/433 ,  A61P31/00