公开(公告)号：EP3356361B1

公开(公告)日：2020-07-08

申请号：EP16788802.3

申请日：2016-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： KHERA, Manoj Kumar ,  MATHUR, Tarun ,  SATTIGERI, Jitendra A. ,  MASUDA,, Nobuhisa ,  SONEDA, Tsuyoshi ,  KAGOSHIMA, Yoshiko ,  KONOSU, Toshiyuki ,  SUZUKI, Tetsuya ,  YAMAOKA, Makoto ,  ITOOKA, Ryo

IPC分类号： C07D417/14 ,  A61K31/433 ,  A61P31/00

公开(公告)号：EP2226322A1

公开(公告)日：2010-09-08

申请号：EP08867971.7

申请日：2008-12-26

申请人： Daiichi Sankyo Company, Limited

发明人： SONEDA, Tsuyoshi ,  TAKESHITA, Hiroshi ,  KAGOSHIMA, Yoshiko ,  YAMAMOTO, YUKO ,  HOSOKAWA, Takafumi ,  KONOSU, Toshiyuki ,  MASUDA, Nobuhisa ,  UCHIDA, Takuya ,  ACHIWA, Issei ,  KUROYANAGI, Junichi ,  FUJISAWA, Tetsunori ,  YOKOMIZO, Aki ,  NOGUCHI, Tetsuji

IPC分类号： C07D417/14 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/538 ,  A61P31/00 ,  A61P31/04 ,  C07D233/66 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/06

CPC分类号： C07D487/04 ,  C07D233/66 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/06 ,  C07D487/12 ,  C07D495/04 ,  C07D495/16 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

摘要翻译： 为了开发具有新的作用机理的抗生素，本发明人已经搜索到具有弱细胞毒性，在水中溶解度高的物理性质，抑制DNA促旋酶GyrB和拓扑异构酶IV ParE亚基的作用的化合物和足够的抗细菌 活动。 结果，本发明人通过发现由通式（1）表示的本发明的化合物，其药理学可接受的盐及其前药具有期望的性质而完成了本发明。 本发明提供一种药物组合物（特别是感染性疾病的预防或治疗组合物），其包含式（1）表示的化合物，其药理学上可接受的盐或其前药作为活性成分。

公开(公告)号：EP3356361A1

公开(公告)日：2018-08-08

申请号：EP16788802.3

申请日：2016-09-28

申请人： Daiichi Sankyo Company, Limited

发明人： KHERA, Manoj Kumar ,  MATHUR, Tarun ,  SATTIGERI, Jitendra A. ,  MASUDA,, Nobuhisa ,  SONEDA, Tsuyoshi ,  KAGOSHIMA, Yoshiko ,  KONOSU, Toshiyuki ,  SUZUKI, Tetsuya ,  YAMAOKA, Makoto ,  ITOOKA, Ryo

IPC分类号： C07D417/14 ,  A61K31/433 ,  A61P31/00

摘要： Problem to be solved. There is a need for a new antibiotic having a novel mechanism of action, which exhibits strong antibacterial activity not only against sensitive bacteria, but also against resistant bacteria thereof, and at the same time possess excellent solubility and safety profile amenable to human use. Solution to the Problem. As a result of intensive research, the present inventors have found that a compound represented by general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof inhibits DNA gyrase GyrB subunit and/or topoisomerase IV ParE subunit, possess excellent solubility and safety profile for use in human for the treatment of bacterial infectious diseases.

公开(公告)号：EP2226322B1

公开(公告)日：2015-01-21

申请号：EP08867971.7

申请日：2008-12-26

申请人： Daiichi Sankyo Company, Limited

发明人： SONEDA, Tsuyoshi ,  TAKESHITA, Hiroshi ,  KAGOSHIMA, Yoshiko ,  YAMAMOTO, YUKO ,  HOSOKAWA, Takafumi ,  KONOSU, Toshiyuki ,  MASUDA, Nobuhisa ,  UCHIDA, Takuya ,  ACHIWA, Issei ,  KUROYANAGI, Junichi ,  FUJISAWA, Tetsunori ,  YOKOMIZO, Aki ,  NOGUCHI, Tetsuji

IPC分类号： C07D417/14 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/538 ,  A61P31/00 ,  A61P31/04 ,  C07D233/66 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/06

CPC分类号： C07D487/04 ,  C07D233/66 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/06 ,  C07D487/12 ,  C07D495/04 ,  C07D495/16 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00