公开(公告)号：EP1884568A1

公开(公告)日：2008-02-06

申请号：EP06745969.3

申请日：2006-05-01

申请人： Daiichi Sankyo Company, Limited ,  Kazusa DNA Research Institute Foundation

发明人： OHARA, Osamu KAZUSA DNA RESEARCH INST. FOUNDATION ,  NAGASE, T. KAZUSA DNA RESEARCH INST. FOUNDATION ,  OHISHI, M. KAZUSA DNA RESEARCH INST. FOUNDATION ,  OKAJIMA, Daisuke Daiichi Sankyo Co Ltd ,  YOKOTA, Hiroshi Daiichi Sankyo Co Ltd

IPC分类号： C12N15/09 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  A61K45/00 ,  A61P25/24 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  G01N33/6896 ,  G01N33/9466 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/304

摘要： The present invention intended to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein and a useful means for preventing and/or treating diseases relating to the gene and the protein, and has provided a DNA comprising nucleotide sequence as set forth in SEQ ID NO: 1 or complementary strand thereof, equivalents of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent and a method for improving depression state, a pharmaceutical composition, and a reagent kit.

摘要翻译： 本发明旨在发现编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供鉴定调节蛋白质功能和/或表达的化合物的方法 以及用于预防和/或治疗与基因和蛋白质有关的疾病的有用手段，并提供了包含如SEQ ID NO：1所示的核苷酸序列或其互补链的DNA，该DNA的等价物，由 该DNA，含有该DNA的载体，含有该载体的转化体，针对该蛋白质的抗体，使用上述成员鉴定调节该蛋白质的功能和/或表达的化合物的方法，改善抑郁状态的药剂和方法 ，药物组合物和试剂盒。