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1.发明授权DIBENZ b,e]OXEPIN DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME AS ACTIVE INGREDIENT 失效二苯并[b，E]氧杂七环衍生物，以及药物THIS作为活性剂包括在内。
公开(公告)号：EP0269755B1
公开(公告)日：1993-11-18
申请号：EP87904092.1
申请日：1987-06-17
IPC分类号： C07D313/12 , C07D405/12 , C07D409/12 , A61K31/335 , A61K31/38 , A61K31/44
CPC分类号： C07D401/12 , C07D313/12 , C07D409/12
摘要： Compound represented by general formula (I), (wherein R1 is H or methoxy, R2 is H, methoxy, OH or F, R3 is H or F, R4 is H or F attached to the 7-, 8- or 9- position, and Ar is benzene, thiophene or pyridine ring, provided that (i) at least two of R1, R2, R3, and R4 are each H, (ii) R2 or R3 is H when R4 is F, (iii) R1, R3 and R4 are each H when R2 is methoxy or OH, (iv) R2 and R3 are not simultaneously F, and (v) R2 and R3 are each H or F, and R1 and R4 are both H when Ar is a thiophene or pyridine ring) or a physiologically acceptable acid addition salt thereof. The compound of the present invention exhibits an excellent resistance to intracerebral anoxia and also often exhibits a peroxidation preventive action of mitochondria membrane lipid and an anticonvulsing action and is useful as preventive and therapeutic medicines for anoxia of cranial nerve cells of mammals including human being.
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2.发明公开DIBENZ b,e OXEPIN DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME AS ACTIVE INGREDIENT 失效DIBENZ [b，e] OXEPINDERIVATE，SOWIE ARZNEIMITTEL，DIE DIESE ALS AKTIC MITTEL ENTHALTEN。
公开(公告)号：EP0269755A1
公开(公告)日：1988-06-08
申请号：EP87904092.1
申请日：1987-06-17
IPC分类号： C07D313/12 , C07D405/12 , C07D409/12 , A61K31/335 , A61K31/38 , A61K31/44
CPC分类号： C07D401/12 , C07D313/12 , C07D409/12
摘要： Compound represented by general formula (I), (wherein R, is H or methoxy, R 2 is H, methoxy, OH or F, R 3 is H or F, R 4 is H or F attached to the 7-, 8- or 9-position, and Ar is benzene, thiophene or pyridine ring, provided that (i) at least two of R 1 , R 2 , R 3 , and R 4 are each H, (ii) R 2 or R 3 is H when R 4 is F, (iii) R,, R 3 and R 4 are each H when R 2 is methoxy or OH, (iv) R 2 and R 3 are not simultaneously F, and (v) R 2 and R 3 are each H or F, and R 1 and R 4 are both H when Ar is a thiophene or pyridine ring) or a physiologically acceptable acid addition salt thereof. The compound of the present invention exhibits an excellent resistance to intracerebral anoxia and also often exhibits a peroxidation preventive action of mitochondria membrane lipid and an anticonvulsing action and is useful as preventive and therapeutic medicines for anoxia of cranial nerve cells of mammals including human being.
摘要翻译： 苯并（b，e）式（I）的氧杂环庚烯及其药学上可接受的酸加成盐。 盐是新的，其中R1 = H或甲氧基; R2是H，甲氧基，羟基或F; R3为H或F; 在7,8或9位上R4是H或F; Ar是（优选的）苯基，噻吩基或吡啶基。 当R4 = F时，R2和/或R3为H.当R2 = OMe或OH时，R1，R3和R4为H. R2和R3不都为F.当Ar 是噻吩基或吡啶基，R2是H或F，R3是H或F，R1 = R4 = H。
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