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    AGENT FOR TREATING ISCHEMIC BRAIN TROUBLE
    2.
    发明公开
    AGENT FOR TREATING ISCHEMIC BRAIN TROUBLE 失效
    MITTEL ZUR BEHANDLUNG DERISCHÄMISCHENGEHIRNKRANKHEIT。

    公开(公告)号：EP0396748A1

    公开(公告)日：1990-11-14

    申请号：EP89900918.7

    申请日：1988-12-27

    申请人： DAINIPPON PHARMACEUTICAL CO., LTD.

    发明人： MASUDA, Yoshinobu ,  KADOKAWA, Toshiaki ,  KUROKAWA, Mikio ,  ZUSHI, Kayoko ,  OCHI, Yoshiaki

    IPC分类号： A61K31/42

    CPC分类号： A61K31/42 ,  C07D261/20

    摘要： An agent for treating ischemic brain troubles which contains 3-sulfamoylmethyl-1,2-benzisoxazole or its alkali metal salt as the active ingredient. This agent can be used for prophylaxis and treatment of intracranial diseases of mammals (including human beings) induced by brain ischemia or various diseases accompanying them.

    摘要翻译： 用于治疗缺血性脑病的药物，其含有3-氨磺酰基甲基-1,2-苯并异恶唑或其碱金属盐作为活性成分。 该药物可用于预防和治疗由脑缺血或伴随的各种疾病诱发的哺乳动物（包括人类）的颅内疾病。

    DIBENZ b,e OXEPIN DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME AS ACTIVE INGREDIENT
    3.
    发明公开
    DIBENZ b,e OXEPIN DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME AS ACTIVE INGREDIENT 失效
    DIBENZ [b，e] OXEPINDERIVATE，SOWIE ARZNEIMITTEL，DIE DIESE ALS AKTIC MITTEL ENTHALTEN。

    公开(公告)号：EP0269755A1

    公开(公告)日：1988-06-08

    申请号：EP87904092.1

    申请日：1987-06-17

    申请人： Dainippon Pharmaceutical Co., Ltd.

    发明人： UNO, Hitoshi ,  KUROKAWA, Mikio ,  SATO, Fiminori ,  NARUTO, Shunsuke ,  MASUDA, Yoshinobu

    IPC分类号： C07D313/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/335 ,  A61K31/38 ,  A61K31/44

    CPC分类号： C07D401/12 ,  C07D313/12 ,  C07D409/12

    摘要： Compound represented by general formula (I), (wherein R, is H or methoxy, R 2 is H, methoxy, OH or F, R 3 is H or F, R 4 is H or F attached to the 7-, 8- or 9-position, and Ar is benzene, thiophene or pyridine ring, provided that (i) at least two of R 1 , R 2 , R 3 , and R 4 are each H, (ii) R 2 or R 3 is H when R 4 is F, (iii) R,, R 3 and R 4 are each H when R 2 is methoxy or OH, (iv) R 2 and R 3 are not simultaneously F, and (v) R 2 and R 3 are each H or F, and R 1 and R 4 are both H when Ar is a thiophene or pyridine ring) or a physiologically acceptable acid addition salt thereof. The compound of the present invention exhibits an excellent resistance to intracerebral anoxia and also often exhibits a peroxidation preventive action of mitochondria membrane lipid and an anticonvulsing action and is useful as preventive and therapeutic medicines for anoxia of cranial nerve cells of mammals including human being.

    摘要翻译： 苯并（b，e）式（I）的氧杂环庚烯及其药学上可接受的酸加成盐。 盐是新的，其中R1 = H或甲氧基; R2是H，甲氧基，羟基或F; R3为H或F; 在7,8或9位上R4是H或F; Ar是（优选的）苯基，噻吩基或吡啶基。 当R4 = F时，R2和/或R3为H.当R2 = OMe或OH时，R1，R3和R4为H. R2和R3不都为F.当Ar 是噻吩基或吡啶基，R2是H或F，R3是H或F，R1 = R4 = H。

    TRYCICLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM
    6.
    发明授权
    TRYCICLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM 失效
    TRYCICLIC或TETRACYCLIC化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：EP0191867B1

    公开(公告)日：1991-10-16

    申请号：EP85904018.0

    申请日：1985-08-09

    申请人： Dainippon Pharmaceutical Co., Ltd.

    发明人： UNO, Hitoshi ,  KUROKAWA, Mikio ,  SATO, Fuminori ,  HATANO, Naonobu

    IPC分类号： C07D213/74 ,  C07D215/38 ,  C07D239/42 ,  C07D295/14 ,  C07D337/12 ,  C07D401/04 ,  C07D409/12 ,  A61K31/495 ,  A61K31/55 ,  A61K31/505

    CPC分类号： C07D215/38 ,  C07D213/74 ,  C07D239/42 ,  C07D277/38 ,  C07D295/15 ,  C07D337/12 ,  C07D409/12

    摘要： Compounds represented by general formula (I) (wherein A represents alkylene, Y-Z represents formula (II), -CH=CH-, -CH2CH2- or formula (III), R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl or phenylsulfonyl, a represents 2 or 3, b and c each represents 1 or 2, and d represents an integer of 0 to 2, provided that the phenyl, phenyl moiety or naphthyl moiety may be substituted) and salts thereof, processess for their preparation, and medicinal compositions containing them. These compounds show a strong calcium-antagonistic effect, and are therefore useful for prophylaxis and treatment of hypertension and/or ischemic heart diseases.

    摘要翻译： PCT No.PCT / JP85 / 00445 Sec。 一九八六年四月十日 102（e）日期1986年4月10日PCT提交1985年8月9日PCT公布。 公开号WO86 / 01203 日期：1986年2月27日。下式的化合物：其中A表示亚烷基; Y-Z表示 -CH = CH-，-CH 2 CH 2 - 或R 1，R 2和R 2各自为取代基; R3是氢原子，烷基或烷氧基; R4是苯基，苯基烷基，苯基链烯基，二苯基甲基，萘基，噻唑基，任选取代的吡啶基，任选取代的嘧啶基，喹啉基，苯甲酰基烷基，苯甲酰基，糠酰基，噻吩甲酰基，苯氧基羰基，苯氧基磺酰基或苯基磺酰基; a为2或3，b和c各自为1或2，d为0至2的整数，条件是苯基，苯基部分和萘基可任选被取代，及其药学上可接受的盐，其制备方法 及含有该组合物的药物组合物。 化合物及其盐显示出有效的钙拮抗活性，可用于预防和治疗高血压和/或缺血性心脏病。