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公开(公告)号:EP3054010A1
公开(公告)日:2016-08-10
申请号:EP14850688.4
申请日:2014-10-03
发明人: SATO, Noriyuki , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , KANASEKI, Takayuki , KOCHIN, Vitaly , TAKAYA, Akari , GOTO, Masashi
IPC分类号: C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K16/28 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574
摘要: The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO-XO-ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.
摘要翻译: 本发明的目的是提供:用于特异性检测癌症干细胞的检测剂; 癌症干细胞特异表现的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物,其含有作为其有效成分的药物组合物; 和筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽,包含至少一种所述肽作为表位肽并且具有连接在其中的多个表位肽的多表位肽,编码至少肽或多表位肽的多核苷酸,药物组合物 含有这些作为其有效成分的化合物,以及以诱导CTL为特征的癌症预防和/或治疗剂。
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公开(公告)号:EP3054010B1
公开(公告)日:2020-07-22
申请号:EP14850688.4
申请日:2014-10-03
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