公开(公告)号：EP3388436B1

公开(公告)日：2020-08-12

申请号：EP18174175.2

申请日：2014-03-17

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. ,  WALLER, David ,  CHOI, Hwan Guen ,  WANG, Jinhua ,  DENG, Xianming

IPC分类号： C07D487/12 ,  C07D487/14 ,  A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00

公开(公告)号：EP3670515A1

公开(公告)日：2020-06-24

申请号：EP20155968.9

申请日：2014-03-17

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. ,  WALLER, David ,  CHOI, Hwan Guen ,  WANG, Jinhua ,  DENG, Xianming

IPC分类号： C07D487/14 ,  C07D487/12 ,  A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00

摘要： The present invention relates to novel pyrimido-diazepinone compounds of formula (I), methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.

公开(公告)号：EP3738964A1

公开(公告)日：2020-11-18

申请号：EP20183712.7

申请日：2014-03-17

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. ,  WALLER, David ,  CHOI, Hwan Guen ,  WANG, Jinhua ,  DENG, Xianming

IPC分类号： C07D487/14 ,  C07D487/12 ,  A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00

摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.

公开(公告)号：EP3388436A1

公开(公告)日：2018-10-17

申请号：EP18174175.2

申请日：2014-03-17

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. ,  WALLER, David ,  CHOI, Hwan Guen ,  WANG, Jinhua ,  DENG, Xianming

IPC分类号： C07D487/12 ,  C07D487/14 ,  A61K31/519 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00

摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.